Problems and dependence - the history of two dimensions. G. Edwards; temperance cultures - concern about alcohol problems in Nordic and English-speaking cultures, H.G. Levine; correlation and causality - notes on epistemological problems in substance abuse research, O.-J. Skog; problems and dependence - chalk and cheese or bread and butter?, C. Drummond; substance-related problems in the context of international classificatory systems, T.F. Babor; drinking problems - the individual in social context, N. Kreitman; the role of culture in the drug question, G. Pearson; detecting individual factors in substance abuse problems, L. Robins; individual susceptibility to alcohol abuse and to ethanol toxity, T.J. Peters; problem definition - the case of the benzodiazepines, M. Lader; the problems perspective - implications for prevention policies, R.G. Smart; treatment strategies within a problems framework, D.C. Drummond; the demands which the problem perspective sets for research, M. Lader, G. Edwards and D.C. Drummond; the meanings of a problem - a debate around a problematic concept.