Advances in Molecular Biology and Targeted Treatment for AIDS

Viral DNA Replication and Integration.- Mechanistic Analysis of HIV-1 Reverse Transcriptase.- Analyses of HIV Integration Components.- DNA Cleaving Activity of Purified Human Immunodeficiency Virus Integration Protein.- A Thermodynamic Analysis of the Binding of Nucleic Acid to HIV-1 Reverse Transcriptase.- Rous Sarcoma Virus gag Gene Sequences Affect Viral RNA Splicing and Stability.- Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets.- Role of Viral Regulatory Genes.- Human-Specific Factors Are Required for Tat-Mediated Trans-Activation of the HIV-1 and HIV-2 LTRs.- Role of the TAR Element in Regulating HIV Gene Expression.- Regulation of HIV-1 Gene Expression by the Tat Protein and the TAR Region.- HIV-1 Tat: A Transcriptional Activator that Recognizes a Structured RNA Target.- HIV-1 Tat Trans-Activates in the Absence of Its Target.- Trans-Activation Requires the Binding of the HIV-1 tat Protein to TAR RNA.- The HIV-1 tat Transactivator Contains an Arginine-Glycine-Aspartyl (RGD) Cell Adhesion Site.- Inhibition of HIV-1 Replication by Mutant Tat Peptides.- RNA-Protein Interactions Required for Rev Mediated Regulation of HIV Gene Expression.- A 5? Splice Site Is Essential for Rev and Rex Regulation of HIV Envelope Protein mRNA Expression.- Molecular Functional Studies of HIV-1 REV and NEF Proteins.- Structure and Function of HIV & SIV Nef Proteins.- Functional Analysis of the HIV-1 Gene Products vif and vpu.- Envelope Structure.- Envelope Pseudotypes of HIV and HTLV.- CD4-Pseudomonas Exotoxin: A Strategy for AIDS Therapy Based on Selective Killing of HIV-Infected Cells.- Binding of a Reduced-Peptide Inhibitor and a Statine-Containing Inhibitor to the Protease from the Human Immunodeficiency Virus.- A T Cell Clonewhich Reflects the Functional Defects Observed in the T Cells of AIDS Patients.- Roles of Nucleocapsid Cysteine Arrays in Retroviral Assembly and Replication: Possible Mechanisms in RNA Encapsidation.- Regulated Proteolytic Processing within Mature Retroviral Capsids.- Red Blood Cells Exposing CD4, As Competitive Inhibitors of HIV-1 Infection.- Antivirals and Gene Therapy.- Gene Therapy for AIDS.- Discovery of a Novel Potent Inhibitor of HIV Infection.- Antiretroviral Activity of Carbocyclic Nucleosides and Potential Use of Inosinate Dehydrogenase Inhibitors.- Lipophilic 6-Halo-2?,3?-Dideoxypurine Nucleosides: Potential Antiretroviral Agents Targeting HIV-Associated Neurologic Disorders.- Antiviral Evaluation of HIV-1 Specific Ribozyme Expressed in CD4+ HeLa Cells.- Resistance of Influenza A Viruses to Amantadine and Rimantadine.