The discovery of adult neurogenesis and of stem cells in the adult brain has changed our view of the mature brain. With new neurons being produced lifelong, brain development does not seem to end and brain plasticity gains a whole different meaning, if the brain's malleability goes beyond synapses and neurites. But adult neurogenesis occurs in two privileged regions only, the hippocampus and the olfactory system.
Since the mid-1990s, the field of adult neurogenesis research has literally exploded. The second edition became necessary, after hundreds of new reports had been published. Most progress has been made with respect to the question of the functional relevance of the new neurons and their contribution to learning and memory.
The book has become a reference resource for everybody interested in adult neurogenesis and stem cell biology of the adult brain. It begins with the historical background and describes in detail adult neurogenesis in the hippocampus as well as the subventricular zone and olfactory bulb. Regulatory mechanisms are discussed in great detail. The subject of neurogenesis outside the "canonical" neurogenic regions of rodents and primates is discussed and an entire chapter is dedicated to adult neurogenesis in different species. The book concludes with a chapter on the provocative hypotheses that link failing adult neurogenesis with diseases such as temporal lobe epilepsy, major depression, schizophrenia, brain tumors, and dementias.
Rezensionen / Stimmen
A very comprehensive, up-to-date and most importantly useful book to those interested in the subject . . . fantastic formatting with key sentences summarising what can be necessarily dense paragraphs * BMA Medical Book Awards 2011 *
Auflage
Sprache
Verlagsort
Zielgruppe
Für höhere Schule und Studium
Für Beruf und Forschung
Primary audience: Graduate students to specialists in neuroscience, neurobiology, and psychology Secondary audience: Educated lay person.
Editions-Typ
Maße
Höhe: 260 mm
Breite: 183 mm
Dicke: 37 mm
Gewicht
ISBN-13
978-0-19-972969-2 (9780199729692)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Gerd Kempermann is Professor at the CRTD, Center for Regenerative Therapies Dresden, and Speaker of the Dresden site of the DZNE, the German Center for Neurodegenerative disease. He works on the question of how genes and activity regulate adult neurogenesis and what the function of new neurons in the adult brain is.
Autor*in
Professor Genomics of Regeneration, CRTD, and Speaker DZNEProfessor Genomics of Regeneration, CRTD, and Speaker DZNE, German Center for Neurodegenerative Disease, Dresden, Germany, Dresden, Germany
Chapter 1. Introduction
Chapter 2. History
Chapter 3. Neural Stem Cells
Chapter 4. Neuronal Development
Chapter 5. Neurogenesis in the Adult Subventricular Zone and Olfactory Bulb
Chapter 6. Adult Hippocampal Neurogenesis
Chapter 7. Technical Notes
Chapter 8. Neurogenic and Non-neurogenic Regions
Chapter 9. Regulation
Chapter 10. Function
Chapter 11. Adult Neurogenesis in Different Animal Species
Chapter 12. Medicine
Index
