There has not, until now, been a single up-to-date volume to provide those in drug R&D with practical information on all aspects of solid dispersion technology for drugs. This forthcoming volume finally provides such a guide and reference. The unified presentation by a team of specialists in this field is designed for practical application. Theoretical concepts are covered for a fuller understanding of current techniques. All significant recent developments are included.
Sprache
Verlagsort
Verlagsgruppe
Zielgruppe
Für Beruf und Forschung
Professionals in drug research and development
Gewicht
ISBN-13
978-1-56676-813-9 (9781566768139)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Klassifikation
Autor*in
Howard University, Washington, DC, USA
Preface
HISTORICAL BACKGROUND OF SOLID DISPERSIONS
FUNDAMENTALS OF SOLID DISPERSIONS
Theory of Dissolution
Dissolution Methods
Definition of Solid Dispersion
Classification of Solid Dispersion
Methods of Preparing Solid Dispersion
Characterization of Solid Dispersion
PHOSPHOLIPIDS AS TOOLS TO IMPROVE DRUG DISSOLUTION
Introduction
Dissolution Theory
Phospholipid as Excipient in Solid Dispersion
Dissolution of Drug-Phospholipid Solid Dispersion
Mechanism of Dissolution
Effect of Phospholipid Composition on Dissolution
Effect of Coprecipitating Solvent
Application of Drug: Phospholipid Coprecipitates in Controlled Release
Stability
Conclusions
USE OF POLYMERS IN SOLID DISPERSION TECHNOLOGY
Introduction
Formulation of Solid Dispersion
Polymers Used in Solid Dispersion
Polymers and Surface Active Agents Combinations
Bioavailability Studies of Polymer-Drug Solid Dispersion Systems
Characterization of Polymer: Drug Solid Dispersion
Problems Associated with Processing and Stability of Solid Dispersion
CYCLODEXTRINS IN SOLID DISPERSIONS
Introduction
Structural Features
Methods of Drug Incorporation
Mechanism of Drug Release
Oral Administration of Cyclodextrins
Index
