Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Chemical Assembly of Antibody-Drug Conjugates.- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers.- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents.- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications.- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates.- Substance P - Saporin for the Treatment of Intractable Pain.- Recombinant immunotoxins for Chronic Inflammatory Disease.- BL22: A milestone in targeting CD22.