List of contributors vii
Foreword xi
1 Introduction 1
Claire Richardson and Huw Golledge
Part 1 Implementing the Three Rs in research using animals 3
2 The Three Rs 5
Adrian Smith and Jon Richmond
3 The design of animal experiments 23
Simon T. Bate and S. Clare Stanford
4 An introduction to laboratory animal genetics 40
Michelle Stewart and Sara Wells
5 Phenotyping of genetically modified mice 54
Jan-Bas Prins and Sara Wells
6 Brief introduction to welfare assessment: a 'toolbox' of techniques 64
Jennifer Lofgren
7 Welfare and 'best practice' in field studies of wildlife 84
Julie Lane and Robbie A. McDonald
8 Legislation and oversight of the conduct of research using animals: a global overview 101
Kathryn Bayne, Javier Guillen, Malcolm P. France and Timothy H. Morris
9 Planning, design and construction of the modern animal facility 122
Ken Applebee, Christopher Sear and Steven Cubitt
10 Environmental enrichment: animal welfare and scientific validity 137
Hanno Wuerbel and Janja Novak
11 Special housing arrangements 150
Mike Dennis
12 Transportation of laboratory animals 171
Sonja T. Chou, Donna Clemons, Nicolas Dudoignon, Guy Mulder and Aleksandar Popovic
13 Nutrition, feeding and animal welfare 191
Graham Tobin and Annette Schuhmacher
14 Attaining competence in the care of animals used in research 220
Bryan Howard and Marcel Gyger
15 The use of positive reinforcement training techniques to enhance the care and welfare oflaboratory and research animals 236
Gail Laule
16 3Rs considerations when using ageing animals in science 251
J. Norman Flynn, Linda Horan, Carl S. Tucker, David Robb and Michael J.A. Wilkinson
17 Euthanasia and other fates for laboratory animals 268
Huw Golledge
18 Ethics review of animal research 281
I. Anna S. Olsson and Peter Sandoe
Appendix 294
Penny Hawkins and Maggy Jennings
Part 2 Species kept in the laboratory 297
Mammals 299
19 The laboratory opossum 301
John L. VandeBerg and Sarah Williams-Blangero
20 Tree Shrews 324
Eberhard Fuchs
Rodentia and Lagomorpha 340
21 The laboratory mouse: Biology, behaviour, enrichment and welfare: first principles and realsolutions for laboratory mice 340
Kathleen R. Pritchett-Corning and Joseph P. Garner
22 The laboratory rat 379
Sietse F. de Boer and Jaap M. Koolhaas
23 The laboratory gerbil 400
Elke Scheibler
24 The Syrian hamster 419
Christina Winnicker and K.R. Pritchett-Corning
25 Voles 430
Petra Kirsch
26 The naked mole-rat (Heterocephalus glaber) 442
Chris G. Faulkes
Appendix A 459
27 The guinea pig 465
Sylvia Kaiser, Christine Krueger and Norbert Sachser
28 The laboratory rabbit 484
Lena Lidfors and Therese Edstroem
Carnivora 506
29 The ferret 506
Maggie Lloyd
30 The laboratory dog 518
Laura Scullion Hall and Jackie Boxall
31 The domestic cat 546
Emma Desforges
Ungulates 570
32 Pigs and minipigs 570
Adrian Zeltner and Henrik Duelund Pedersen
33 Cattle 596
Ute Weyer and Shellene Hurley
34 Sheep and goats 609
Colin L. Gilbert and Cathy M. Dwyer
35 The Horse 628
Heather Ewence and Fleur Whitlock
Non-Human Primates 662
36 The mouse lemurs 662
Jennifer Wittkowski, Annette Klein, Annika Kollikowski, Marina Scheumann, Daniel Schmidtke, Elke Zimmermann and Ute Radespiel
37 Marmosets and tamarins 683
Hannah M. Buchanan-Smith
38 Capuchin monkeys 707
James R. Anderson, Elisabetta Visalberghi and Arianna Manciocco
39 Old world monkeys 721
Jaco Bakker, Annet L. Louwerse, Marit K. Vernes and Jan A.M. Langermans
Birds 739
40 The domestic fowl 741
Ian J.H. Duncan
41 The Japanese quail 762
Rusty Lansford and Kimberly M. Cheng
42 The zebra finch 787
Ruedi G. Nager, Michael J.A. Wilkinson and Graham Law
43 Pigeons and doves 807
Stephen E.G. Lea, Anthony McGregor, Mark Haselgrove and Catriona M.E. Ryan
44 The European starling 824
Melissa Bateson
45 Corvids 839
Rachael Miller, Martina Schiestl and Nicola S. Clayton
Reptiles and Amphibia 853
46 Terrestrial reptiles: lizards, snakes and tortoises 855
John E. Cooper
47 An amphibian 'laboratory model', Xenopus 881
Richard Tinsley
Fish 905
48 Fishes 907
Sonia Rey Planellas and Carlos Garcia de Leaniz
49 Zebrafish 933
Carole Wilson
Cephalopoda 957
50 Cephalopoda 959
Meghan Holst, Ryan B. Howard and Robyn J. Crook
Decapoda 991
51 Decapod crustaceans 993
Robert W. Elwood and Ray W. Ingle
Index 1012
