Part 1 General considerations: epidemiology - comorbidity of substance use and psychiatric disorders; genetics - models of transmission of substance use and common comorbid psychiatric disorders; overview of diagnostic methods - clinical interviews, semi-structured and structured interviews, biological markers; overview of treatment modalities and settings - pharmacotherapy, psychotherapy, 12-step programmes. Part 2 Specific comorbid conditions - diagnosis and treatment: alcoholism and mood disorders; alcoholism and anxiety disorders; drug abuse and mood disorders; drug abuse and anxiety disorders; comorbidity of smoking with other substance use and psychiatric disorders; substance abuse and psychological trauma; substance abuse and personality disorders; substance abuse and eating disorders; substance abuse and attention deficit disorder; substance abuse and schizophrenia; substance abuse and traumatic brain injuries; substance abuse and HIV-related disease; other medical disorders in substance abuse patients.