A Selection of the Contents. Biotechnology Focus. Enzyme-based electrochemical biosensors (R.K. Kobos). Direct microanalysis by negative-ion fast atom bombardment mass spectrometry (R. Isobe, I. Fujii, K. Kanematsu). Computer Corner. A comparison of Lisp and Prolog (G.J. Postma, B.G.M. Vandeginste, C.J.G. van Halen, G. Kateman). Correspondence analysis on a microcomputer (A. Thielemans, D.L. Massart). Chemical applications of Prolog. Interpretation of mass spectral peaks (G.J. Kleywegt, H.A. van 't Klooster). Interface. HPLC method-development using computer simulation (L.R. Snyder, J.W. Dolan, M.A. Quarry). Robotics for the bioanalytical laboratory. A flexible system for the analysis of drugs in biological fluids (H.G. Fouda, R.P. Schneider). Feature. An introduction to supercomputers (P.K. Hopke, L. Kaufman). Flow-injection analysis: beyond the laboratory curiosity stage (G.E. Pacey, B.P. Bubnis). Trends. Supercritical-fluid chromatography - prospects and problems (P.J. Schoenmakers, F.C.C.J.G. Verhoeven). In vivo sensors (D. Diamond, G. Svehla). GC-FTIR-MS. A powerful tool for component identification in complex organic mixtures (J.C. Demirgian). Trends in fiber optic sensor developments (L.A. Saari). Direct analysis of thin-layer chromatograms and electrophoretograms by secondary ion mass spectrometry (K.L. Busch). Indirect detection in HPLC (G. Schill, J. Crommen). Trends in stationary phases in HPLC (K.K. Unger, B. Anspach). Analytical controlled-potential coulometry (J.E. Harrar). Measurements of anisotropic interactions in solid-state NMR (T. Terao). Thermospray sample introduction for atomic spectrometry (J.A. Koropchak, D.H. Winn). The present and future of graphite furnace atomic absorption spectroscopy (W. Slavin). Industrial application of preparative liquid chromatography (M. Verzele). Optical waveguide techniques for structural and chemical analysis in thin film and interfacial systems (P.W. Bohn). Photochemistry in medicine. Techniques for analysis of photodegradation pathways of medicinal compounds (D.E. Moore). Chemical measurement and data reduction from a systems analysis perspective (S.D. Brown). Automated method selection for HPLC analysis of drugs (M. De Smet, D.L. Massart). High-field NMR, a powerful new analytical tool (P.C.M. van Zijl). Progress in application of field-flow fractionation in biopolymer analysis (J. Janca). Element-selective chromatographic detection by plasma atomic emission spectroscopy (P.C. Uden).