Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.
The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.
Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Rezensionen / Stimmen
"...one of the few volumes that provide an overview of a field that will increasingly impact us in our daily work, and to which pathologists have a great deal to contribute." (Veterinary Pathology, November 2005)
Auflage
Sprache
Verlagsort
Zielgruppe
Für Beruf und Forschung
Toxikologen, Gentechnologen, Arbeitsmediziner, Pharmakologen
Illustrationen
41
127 s/w Abbildungen, 57 s/w Tabellen, 41 farbige Abbildungen
Illustrations
Maße
Höhe: 24 cm
Breite: 17 cm
Dicke: 40 mm
Gewicht
ISBN-13
978-3-527-30342-7 (9783527303427)
Schweitzer Klassifikation
Jürgen Borlak received a degree in biochemistry and a PhD in biochemical toxicology at the University of Reading, UK, in 1988. He was a Cancer Research Campaign-founded postdoctoral research scientist and in 1990 joined the Marion Merrel Dow Research Institute in Strasbourg, France, as Senior Research Biochemist. In 1998, he was appointed Director of the Center of Drug Research and Molecular Pharmacology at the Fraunhofer Institute of Toxicology and Experimental Medicine; the centre focuses largely on the molecular effects of drugs and xenobiotics, using a wide range of methods and technologies in cell biology, genomics and molecular biology. In 2000 Jürgen Borlak was habilitated in pharmacology and toxicology and received the venia legendi at the Medical School of Hannover. In 2002 he was appointed as full professor to the chair of Pharmaco- and Toxicogenomics at the Medical School of Hannover. He was also appointed as Professor of Molecular Anatomy at the Medical Faculty of the University Leipzig in 2003.
Jürgen Borlak is a member of, among others, the Biochemical Society, the Royal Society of Chemistry, the Society of Experimental Biology and the International Society for the Study of Xenobiotics. He is a reviewer for various scientific journals and appointed by the World Health Organisation as an expert on chemical and drug safety.
Introduction
TECHNOLOGY PLATFORMS IN TOXICOGENOMICS
Expression Profiling Using SAGE and cDNA Arrays
Oligo Arrays, Global Transcriptom Analysis
Toxicogenomics Applications of Open-Platform High Density DNA Microarrays
Mass Spectrometry and Proteomics: Principles and Applications
Covalent Protein Modification Analysis by Electrospray Tandem Mass Spectrometry
Chromatin Immunoprecipitation-based Identification of Gene Regulatory Networks
NMR Spectroscopy as a Versatile Analytical Platform for Toxicology Research
BIOINFORMATIC TOOLS IN TOXICOGENOMICS
Generation and Validation of a Reference System for Toxicogenomics DNA Microarray Experiments
The Chemical Effects in Biological Systems (CEBS) Knowledge Base
Investigating the Effective Range of Agents Using Integrative Modelling
Databases and Tools for In-silico Analysis of Regulation of Gene Expression
System Biology Applied to Toxicogenomic
APPLICATION OF TOXICOGENOMIC: CASE STUDIES
Networks of Liver-enriched Transcription Factors in Liver Biology and Disease
Toxicogenomics Applied to Understanding Cholestasis and Steatosis in the Liver
Toxicogenomics Applied to Cardiovascular Toxicity
Toxicogenomics Applied to Endocrine Disruption
Toxicogenomics Applied to Teratogenicity Studies
Toxicogenomics Applied to Nephrotoxicity
Toxicogenomic Analysis of Human Umbilical Cords to Establish a New Risk Assessment of Human Fetal Exposure to Multiple Chemicals
Genetic Variability: Implications for Toxicogenomic Research
Profiling of Peripheral Blood Gene Expression to Search for Biomarkers
How Things Could Be Done Better Using Toxicogenomics: A Retrospective Analysis
Toxicogenomics Applied to Haematotoxicology
THE NATIONAL TOXICOGENOMIC PROGRAM/ INITIATIVES
The National Toxicogenomic Program
Toxicogenomics: The Japanese Initiative
POINT OF VIEW FROM REGULATORY AUTHORITIES
Toxicogenomics in Need for an ICH Guideline? Experiences from the Past
