Introduction; Perspective; The Howard Gilman Foundation Lecture. Where Have We Come From and Where Are We Going? Valve Management Past, Present and Future: Perloff, J.K.; Epidemiology and Pathophysiology; The Epidemiology of Valvular Heart Diseases: The Problem is Growing: Supino, P.G.; Borer, J.S.; Yin. A.; Dillingham, E.; McClymont, W.; Heart Failure in Aortic Regurgitation: The Role of Primary Fibrosis and Its Cellular and Molecular Pathophysiology: Borer, J.S.; Truter, S.L.; Gupta, A.; Herrold, E.M.; Carter, J.N.; Lee, E.; Pitlor, L.; Is Prophylactic [beta]-Adrenergic Blockade Appropriate in Mitral Regurgitation: Impact of Cellular Pathophysiology: Sterling, M.R.; Aortic Valve and Aortic Root Diseases Valve Surgery in the Asymptomatic Patient with Aortic Regurgitation: Current Indications and the Effect of Change Rates in Objective Measures: Borer, J.S.; Supino, P.G.; Hochreiter, C.; Herrold, E.M.; Yin, A.; Krieger, K.; Isom, O.W.; Valve Repair versus Replacement When Aortic Regurgitation Is Caused by Aortic Root Aneurysms: Relative Advantages and Disadvantages and the Impact of Decision on Surgical Indications: Girardi, L.N.; Assessment of Myocardial Damage in Regurgitant Valvular Disease: Narula, J.; Cholesterol-Lowering Studies for Aortic Stenosis: Rosenbluth, A.; Fuster, V.; Perspectives on Diseases of the Thoracic Aorta: Elefteriades, J.A.; Mitral and Tricuspid Valve Diseases; Natural History of Mitral Stenosis and Echocardiographic Criteria and Pitfalls in Selecting Patients for Balloon Valvuloplasty: Berger, M.; Surgical Treatment of Degenerative Mitral Regurgitation: Should We Approach Differently Patients with Flail Leaflets of Simple Mitral Valve Prolapse? Enriquez-Sarano, M.; Avierinos, J.-F.; Ling, L.H.; Grigioni, F.; Mothy, D.; Tribouilloy, C.; Ventricular Arrhythmias in Mitral Regurgitation: Frequency, Clinical and Prognostic Importance. Management Before and After Mitral Valve Surgery: Hochrreiter, C.; Borer, J.S.; Yin, A.; Supino, P.G.; Herrold, E.M.; Krieger, K.; Isom, O.W.; The Case for Bioprosthetic Mitral Valve Replacement in Patients Aged 60-70: Chatterjee, S.; Jayasanker, V.; Gardner, T.J.; Endocardial Cushion Defects: Embryology, Anatomy and Pathophysiology: Cooper, R.S.; Surgery for Atrioventricular Septal Defects: Ouaegebeur, J.M.; Cooper, R.S.; When Should Tricuspid Valve Replacement/Repair Accompany Mitral Valve Surgery? Gold, J.P.; Surgical Considerations and Combined Valvular plus Ischemic Heart Disease; Strategies for Management of Postcardiotomy Cardiogenic Shock following Valvular Heart Surgery: Vigllance, D.W.; Oz, M.C.; Neurological Dysfunction after Coronary Artery Bypass Surgery: Facts vs. Fiction: Krieger, K.; Robotic Valve Surgery: How Does the Future Look? Morgan, J.A.; Argenziano, M.; Smith, C.R.; Selection of Techniques for Combined Valve Surgery and Coronary Artery Bypass Grafting: The Impact of Combined Procedures Involving the Aortic or Mitral Valve: Cohn, L.H.; Soltesz, E.G.; Aortic Valve and Non-Ischemic Mitral Valve Surgery in Patients Undergoing Coronary Artery Bypass Grafting: Schwartz, C.F.; Saunders, P.C.; Gelloway, A.C.; Echocardiographic Doppler Evaluation of Prosthetic Valve Function and Dysfunction: Goldman, M.E.; Author Index; Subject Index