Part 1 Introduction - Summary of Recommendations: Coding System; Substance Use Disorders - General Treatment Principles and Alternatives; Alcohol Use Disorders - Treatment Principles and Alternatives; Cocaine Use Disorders - Treatment Pinciples and Alternatives; Opioid Use Disorders - Treatment Principles and Alternatives. Part 2 Disease Definition, Epidemiology, and Natural History: DSM-IV Criteria for Substance Dependence and Abuse; Disease Definition and Diagnostic Features; Natural History and Course; Epidemiology. Part 3 General Treatment Principles and Alternatives: Goals of Treatment; Assessment; Psychiatric Management; Pharmacological Treatmetns; Psychosocial Treatments; Formulating and Implementing a Treatment Plan; Treatment Settings; Clinical Features Influencing Treatment; Legal and Confidentiality Issues. Part 4 Alcohol-Related Disorders - Treatment Principles and Alternatives: Overview; Choice of Treatment Setting; Pharmacological Treatments for Dependence and Abuse; Psychosocial Treatments; Clinical Features Influencing Treatment. Part 5 Cocaine-Related Disorders - Treatment Principles and Alternatives: Overview; Choice of Treatment Setting; Pharmacological Treatments for Dependence and Abuse; Psychosocial Treatments; Clinical Features Influencing Treatment. Part 6 Opioid-Related Disorders - Treatment Principles and Alternatives: Overview; Choice of Treatment Setting; Pharmacologic Treatments for Dependence and Abuse; Psychosocial Treatments; Clinical Features Influencing Treatment. Part 7 Research Directions. Part 8 Development Process. Part 9 Individuals and Organisations That Submitted Comments.