Neurobiology of Opioids

Section I General Aspects.- 1 Opioid Receptor Subtypes: Past, Present and Future.- 2 Opioid Peptide Genes: Structure and Regulation.- 3 Distribution of Opioids in Brain and Peripheral Tissues.- Section II Opioid Receptor Biochemistry and Signal Transduction.- 4 Multiple Opioid Receptors.- 5 Molecular Approaches to Isolating Opioid Receptors.- 6 Interactions Between Opioid Receptors and Guanine Nucleotide Regulatory Proteins in Intact Membranes: Studies in a Neurotumor Cell Line.- 7 Guanine Nucleotide Binding Proteins and Their Coupling to Opioid Receptors.- 8 Opioid Receptors and Ion Channels.- 9 Cellular Signaling Mechanisms Regulating Opioid Peptide Gene Expression.- Section III CNS Opioidergic Systems: Distribution and Modulation.- 10 Central Distribution of Opioid Receptors: A Cross-Species Comparison of the Multiple Opioid Systems of the Basal Ganglia.- 11 Modulation of Central Opioid Receptors.- 12 The Control of Hypothalamic Opioid Peptide Release.- 13 Modulation of Catecholamine Release in the Central Nervous System by Multiple Opioid Receptors.- Section IV Functional Aspects.- 14 Adaptation of Opioid Systems to Stress.- 15 Endogenous Opioid Systems in the Control of Pain.- 16 Opioid Interactions with Other Neuropeptides in the Spinal Cord: Relevance to Nociception.- 17 Opioid Analgesia at Peripheral Sites.- 18 Regulation of Intestinal Motility by Peripheral Opioids: Facts and Hypotheses.- 19 A Neuroendocrine Perspective of Sex and Drugs.- 20 Motivational Aspects of Opioids: Neurochemical and Neuroanatomical Substrates.- 21 Psychotomimetic Effects of Opioids.- 22 Psychiatric Aspects of Opioid Research.- 23 Functional Correlates of Opioid Receptor Activation as Measured by Local Cerebral Glucose Utilization.- Section V Opioid Tolerance and Dependence.- 24 Tolerance and Physical Dependence: Physiological Manifestations of Chronic Exposure to Opioids.- 25 Aspects of Opioid Tolerance and Dependence in Peripheral Nervous Tissues.- 26 Overview of Opioid Tolerance and Physical Dependence.- Section VI Epilogue.- 27 Some Thoughts on the Present Status and Future of Opioid Research.