Dedication Preface Contributors I. Definition, Epidemiology and Mechanisms 1. Definitions and Epidemiology of Sudden Cardiac Death R.J. Myerburg et al. 2. The Classification of Sudden Death in Clinical Trials L.J.M.C. Jordens 3. How Genetics May Help to Understand and Prevent Sudden Cardiac Death K. Schwartz 4. Autonomic Nervous System and Sudden Cardiac Death H. Calkins 5. Apoptosis and Sudden Cardiac Death Z. Mallat, B. Hugel, G. Leseche, J-M. Freyssinet, A. Tedgui 6. Spatiotemporal Organization of Ventricular Fibrillation Increases during Global Ischemia in the Isolated Rabbit Heart J. Chen, R. Mandapati, O. Berenfeld, M. Mansour, J. Jalife 7. The Role of Early Afterdepolarizations in Lethal Ventricular Arrhythmias R. Lazzara, B. Szabo 8. Regional Differences in Electrophysiology of Ventricular Cells: Clinical Implications for Sudden Cardiac Death C. Antzelevitch 9. Nonfibrillatory Sudden Cardiac Death: Role of Bradycardia J-J. Blanc, J. Mansourati 10. Sudden Cardiac Death: The Pathology Perspective M. Davies II. Out of Hospital Sudden Cardiac Death 11. Automated External Defibrillation in Europe L. Bossaert 12. The Maastricht Study: A Plea for New Approaches to Improve Results of Out-of-Hospital Resuscitation H.J.J. Wellens, J. de Vreede-Swagemakers, A. Lousberg, A.M. Gorgels 13. European Resuscitation Council Guidelines for Resuscitation of the Adult Cardiac Arrest Victim L. Bossaert 14. Evidence-Based Guidelines in Resuscitation: From Experiment to Guidelines L.B. Becker III. Normal Heart, Sports, and Sudden Cardiac Death 15. Sudden Cardiac Death in Young Athletes: Epidemiology, Screening, and Prevention B.J. Maron 16. Idiopathic Ventricular Fibrillation S.G. Priori, L. Crotti 17. Why Patients with Arrhythmogenic Right Ventricular Dysplasia Die Suddenly G. Fontaine, P. Fornes, Z. Mallat, F. Fontaliran, R. Frank 18. Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: A Genetic or an Acquired Disease? D. Corrado, C. Basso, M. Valente, G. Thiene 19. Therapies for Prevention of Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy T. Wichter, M. Borggrefe, D. Boecker, G. Breithardt V. Sudden Cardiac Death and Repolarization 20. The Long QT Syndrome: From Genotype to Phenotype P.J. Schwartz 21. Congenital Long QT Syndrome: Therapeutic Considerations Based on the International LQTS Registry A.J. Moss, W. Zareba 22. Brugada Syndrome: From Genetics to Clinical Management P. Brugada, J. Brugada, R. Brugada, J. Tobin, C. Antzelevitch VI: Heart Failure 23. Are There Specific Risk Markers of Sudden Cardiac Death in Heart Failure Patients? J.Y. Le Heuzey et al. 24. Sudden Cardiac Death in Idiopathic Dilated Cardiomyopathy P. Cosnay et al. 25. Mechanisms of Sudden Death in Hypertrophic Cardiomyopathy: Implications for Risk Stratification P. Sorajja, P.M. Elliott, W.J. McKenna 26. Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathies R. Cappato 27. The Implantable Cardioverter-Defibrillator as a Bridge to Transplantation: Is it Worthwhile? A. Raviele VII: Pediatrics 28. Neuromuscular Disorders and Sudden Death D. Duboc et al. 29. Sudden Cardiac Death After Surgery of Congenital Cardiac Diseases E. Villain VIII: Etiologies 30. Sudden Death in Mitral Valve Prolapse J-P. Fauchier et al. 31. Sudden Death in Patients with Cardiac Conduction Disorders H.E. Kulbertus 32. Myocarditis: An Underestimated Cause of Sudden Cardiac Death C. Basso, F. Calabrese, D. Corrado, G. Thiene IX: Ischemia and Sudden Cardiac Death 33. Arrhythmias in Acute Ischemia M.J. Janse 34. Mechanisms of Ventricular Arrhythmias in the Subacute and Late Post-Infarction Period N. El-Sherif, B. Huang, D.O. Kozhevnikov X: Markers of Sudden Cardiac Death in the Era of Revascularization 35. Usefulness of Premature Ventricular Contractions and Late Potentials for Risk Stratification after Myocardial Infarction in the Era of Revascularization S. Kacet, C. Kouakam 36. Baroreflex Sensitivity and Heart Rate Variability: State of the Art and Perspective M. Malik, I. Savelieva 37. Markers of Sudden Cardiac Death. Clinical Usefulness of the QT Study: QT Duration, QT Dispersion, QT Dynamicity, and T-Wave Alternans A. Leenhardt, P. Maison Blanche, F. Extramiana, P. Milliez, P. Coumel 38. Value of Programmed Ventricular Stimulation to Select Candidates at Risk for Sudden Cardiac Death E.N. Prystowsky 39. Value of Left Ventricular Function Stratification K. Isaaz 40. Nonsustained Ventricular Tachycardia: Prognostic and Therapeutic Considerations N. Saoudi, F. Anselme, M. Chalumeau, A. Savoure, A. Cribier XI: Prevention 41. The Role of Stress in Sudden Death: Can it be Prevented? P. Coumel 42. Can Diet Prevent Sudden Cardiac Death? M. de Lorgeril XII: Medical Therapy 43. Mechanisms of Defibrillation N. Chattipakorn, R.E. Ideker 44. Can Nonarrhythmic Drugs Prevent Sudden Cardiac Death? E. Aliot, C. de Chillou, I. Magnin-Poull, N. Sadoul XIII: Nonmedical Therapy 45. Ventricular Tachycardia Antiarrhythmic Surgery: The Legacy G.M. Guiraudon G.J. Klein, C.M. Guiraudon XIV: Automatic Implantable Cardioverter-Defibrillators 46. A Critical Appraisal of Implantable Cardioverter-Defibrillator/Drug Trials in the Secondary Prevention of Sudden Cardiac Death G.V. Naccarelli, D.L. Wolbrette, H.T. Patel, J.C. Luck 47. Quality of Life in Patients with Implantable Cardioverter-Defibrillators C. Wolpert, W. Jung, S. Herwig, B. Luderitz 48. Economic Aspects of Implantable Cardioverter-Defibrillator Therapy O.A. Obel, A.J. Camm 49. Can We Learn From Ongoing Implantable Cardioverter-Defibrillator Trials? M. Fromer 50. The Future: A Hybrid Therapy S. Saksena Index