Detection of drugs at low concentration is required in a variety of biological and medical situations, in order to avoid harmful side effects posed by some drug residues. The book details the instrumentation, detection, and application of nano chromatography (that is, any chromatographic and capillary electrophoretic method dealing with the detection of a sample at nano gram per liter or lower) and capillary electrophoresis in the analyses of biological and environmental samples. Methods discussed include: Nano Gas Chromatography, Nano Capillary Electrophoresis, Nano Chiral Chromatography, Micellar Electrokinetic Chromatography, Supercritical Fluid Chromatography, and Nano High Performance Liquid Chromatography.
Rezensionen / Stimmen
"This book will be useful for researchers, academicians and students in analytical chemistry, environmental monitoring and drugs analyses, and professionals of pharmaceutical, agrochemical and other chemical industries." (Chemistry Journals, 11 April 2011)
Produkt-Info
Auflage
Sprache
Verlagsort
Zielgruppe
Produkt-Hinweis
Maße
Höhe: 241 mm
Breite: 163 mm
Dicke: 25 mm
Gewicht
ISBN-13
978-0-470-17851-5 (9780470178515)
Schweitzer Klassifikation
Imran Ali, PhD, is Associate Professor at the Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, India. Dr. Ali has published more than 150 scholarly works, including complete books, book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations.
Hassan Y. Aboul-Enein, PhD, is a Professor at Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt. He has published more than 600 articles, including several books and encyclopedia chapters.
Vinod K. Gupta is a Professor in the Department of Chemistry, Indian Institute of Technology, Roorkee, India. He has published more than 200 articles including book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations.
Chapter 1: Introduction.
1. Nano Analyses.
2. Definition of Nano-Chromatography and Nano-Capillary Electrophoresis.
3. Nano-Chromatography and Nano-Capillary Electrophoresis.
4. Fabrication of Micro Devices.
5. Development in Nano Analyses.
6. Data Integration.
7. Protocol of Nano Analyses.
8. Scope of the Book.
9. Conclusion.
10. References.
Chapter 2: Fabrication of Micro Chips.
1. Introduction.
2. Substrates.
3. Techniques of Fabrication.
3.1 Glass Chips.
3.2 Quartz Chips.
3.3 Silica Chips.
3.4 Polymer Chips.
3.5 Plastic Chips.
3.6 Chips and PCR.
4. Surface Modification.
4.1 Modification by Polymers.
4.2 Modification by Silica Gel.
4.3 Modification by Monolithics.
4.4 Modification by Sulfonation.
5. Designs of Chips.
6. Bindings of Chips.
7. Conclusion.
8. References.
Chapter 3: Instrumentation of Nano-Chromatogrpahy and Nano-Capillary Electrophoresis.
1. Introduction.
2. Nano-Liquid Chromatography.
2.1 Mobile Phase Reservoirs.
2.2 Mobile Phases and Flow Calibration.
2.3 Mobile Phase Tubings.
2.4 Solvent Delivery Pump.
2.6 Sample Injector.
2.7 Separation Chips.
2.8 Detectors.
2.9 Recorder.
2.10 Sample Preparation Units.
3. Nano Capillary Electrophoresis.
3.1 Separation Chip.
3.2 Background Electrolyte and its Reservoirs.
3.3 Sample Injection Port.
3.4 Detectors.
3.5 Recorder.
3.6 Sample Preparation Units.
4. Conclusion.
5. References.
Chapter 4: Detection in Nano Chromatography and Nano Capillary Electrophoresis.
1. Introduction.
2. Mass Spectrometer Detectors.
3. Fluorescence Detectors.
4. Electrochemical Detectors.
5. Element Specific Detectors.
6. Miscellaneous Detectors.
7. Conclusion.
8. References.
Chapter 5: Sample Preparation in Nano Chromatography and Nano-Capillary Electrophoresis.
1. Introduction.
2. Sample Preparation.
3. Sampling.
3.1 Biological Samples.
3.1.1 Blood.
3.1.2 Urine.
3.1.3 Tissues.
3.1.4 Plants.
3.1.5 Food Stuffs.
3.2 Environmental Samples.
3.2.1 Air.
3.2.2 Water.
3.2.3 Sediment and Soils.
4. Preservation.
5. Filtration.
6. Digestion/Homogenization.
7. Extractions.
8. Clean-Up.
9. Pre-concentration.
10. Off-Line Nano-Sample Preparation Methods.
10.1 Nano Solid Phase Extractions.
10.2 Nano Membrane Extractions.
10.3 Nano Miscellaneous Extractions.
11. On-Line Nano-Sample Preparation Methods.
12. Conclusion.
13. References.
Chapter 6: Nano High Performance Liquid Chromatography.
1. Introduction.
2. Nano-HPLC.
3. Applications.
3.1 Nano-HPLC of Biological Matrices.
3.1.1 Proteomics.
3.1.2 Drugs Development and Design.
3.1.3 Environmental Analysis.
4. Optimization of Separations in Nano-HPLC.
5. Trouble Shooting in Nano-HPLC.
6. Conclusion.
7. References.
Chapter 7: Nano Capillary Electro-Chromatography and Nano Micellar Electrokinetic Chromatography.
1. Introduction.
2. Nano Capillary Electro-Chromatography.
2.1 Biological Samples.
2.2 Environmental Samples.
2.3 Mechanism of Separation.
3. Nano Micellar Electrokinetic Chromatography.
3.1 Biological Samples.
3.2 Environmental Samples.
3.3 Mechanisms of Separation.
4. Conclusion.
5. References.
Chapter 8: Nano Capillary Electrophoresis.
1. Introduction.
2. Optimization.
3. Applications.
3.1 Proteomics.
3.2 Genomics.
3.3 Amino Acids.
3.4 Drugs Development and Design.
3.5 Enzymes and Hormones.
3.6 Biological Fluids.
3.7 Foods and Beverages.
3.8 Viruses and Bacteria.
3.9 Explosives.
3.10 Environmental Analyses.
3.11 Miscellaneous Applications.
4. Mechanism of Separation.
5. Conclusion.
6. References.
Chapter 9: Chiral Separations by Nano Liquid Chromatography and Nano Capillary Electrophoresis.
1. Introduction.
2. Nano Liquid Chromatography.
3. Nano Capillary Electrophoresis.
4. Mechanisms of Chiral Separations.
5. Conclusion.
6. References.
Chapter 10: Perspectives of Nano Analyses.
1. Introduction.
2. Future of Micro Fluidic Devices.
3. Future Challenges.
4. Conclusion.
5. References.
