Today, among the various chiral discrimination methods, chromatography and capillary electrophoresis techniques have become powerful tools in environmental analysis. Therefore, there is a need to describe the art of the determination of the chiral pollutants in the environmental matrices. This book provides the complete information on the types of the chiral pollutants, their toxicities and methods of determination by chromatography and capillary electrophoresis.
Rezensionen / Stimmen
"...serves as already source of information on various aspects of chiral compounds and their toxicity." (E-STREAMS, February 2005) "...a very timely book, well illustrated and referenced (up to 2003) and very pleasant to read..." (International Journal of Environmental Analytical Chemistry, Vol.84, No.14 - 15, 10 - 20 December 2004)
Produkt-Info
Auflage
Sprache
Verlagsort
Zielgruppe
Maße
Höhe: 23.7 cm
Breite: 16.5 cm
Dicke: 2.6 cm
Gewicht
ISBN-13
978-0-470-86780-8 (9780470867808)
Schweitzer Klassifikation
Dr Imran Ali obtained his M.Sc. (1986) and Ph.D. (1990) degrees from the Indian Institute of Technology, Roorkee, India. At present, he is working as a Scientist in the National Institute of Hydrology, Roorkee, India. His research areas of interest are the chiral analysis of biologically and environmentally active chiral compounds, and metal ion speciation using chromatographic and capillary electrophoresis techniques. He also has expertise in water quality and wastewater treatment methodologies. Dr Ali is the author or co-author of more than 70 journal articles, book and encyclopedia chapters, and of a book entitled Chiral Separations by Liquid Chromatography and Related Technologies, published by Marcel Dekker, Inc., in New York. Dr Ali has been awarded a 'Khosla Research Award - 1987' by The Indian Institute of Technology, Roorkee, India, for work on the chiral resolution of amino acids. He is a life member of the Indian Science Congress Association.
Professor Hassan Y. Aboul-Enein is a Principal Scientist and Head of the Pharmaceutical Analysis and Drug Development Laboratory at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. He is the author or co-author of over 500 refereed journal articles, 30 book chapters and 270 conference presentations. He is the author of six books, including Chiral Separation by Liquid Chromatography and Related Technologies (Marcel Dekker, Inc.) and The Impact of Stereochemistry on Drug Development and Use (John Wiley&Sons, Ltd). He is amember of the Editorial Board of several journals, including Talanta, Chirality, Biomedical Chromatography, Analytical Letters, Talanta and Chromatographia.
Professor Aboul-Enein is a member of the World Health Organization (WHO) advisory panel on international pharmacopeia and pharmaceutical preparations, and he is a Fellow of the Royal Society of Chemistry (UK). He received his B.Sc. degree (1964) in pharmacy and pharmaceutical chemistry from Cairo University, Cairo, Egypt, and his M.Sc. (1969) and Ph.D. (1971) degrees in pharmaceutical and medicinal chemistry from the University of Mississippi, Oxford, USA. Professor Aboul-Enein's current research interests are in the field of pharmaceutical and biomedical analysis and drug development, with a special emphasis on chiral chromatography, ion-selective electrodes and other separation techniques.
Preface.
Acknowledgements.
About the Book.
About the Authors.
1 Introduction.
1.1 The Importance of the Environment.
1.2 Environmental Pollutants.
1.3 Chirality and its Occurrence.
1.4 The Chemical Evolution of Chirality.
1.5 The Electronic Theory of Chirality.
1.6 The Importance of Chirality.
1.7 Nomenclature for Chiral Pollutants.
1.8 Chirality in Environmental Pollutants.
1.9 Chirality and its Consequences in the Environment.
1.10 The Enantiomeric Ratio and Fractions of Chiral Pollutants.
1.11 Methods for the Separation of Chiral Pollutants.
1.12 Chiral Selectors in Chromatography and Capillary Electrophoresis.
1.13 Detection in Chromatography and Capillary Electrophoresis.
1.14 Other Methods of Separation of Chiral Pollutants.
References.
2 Chiral Pollutants: Sources and Distribution.
2.1 Introduction.
2.2 Sources of Contamination.
2.3 The Distribution of Chiral Pollutants.
2.4 Conclusions.
References.
3 Chiral Pollutants: Biotransformation, Biodegradation and Metabolism.
3.1 Introduction.
3.2 The Mechanisms of the Interactions of Chiral Xenobiotics in Biological Systems.
3.3 The Fate of Chiral Pollutants in the Ecosystem.
3.4 Photochemical Conversion.
3.5 Metabolism.
3.6 Conclusions.
References.
4 The Enantioselective Toxicities of Chiral Pollutants.
4.1 Introduction.
4.2 The Enantioselective Toxicities of PCBs.
4.3 The Enantioselective Toxicities of HCH.
4.4 The Enantioselective Toxicities of Other Chlorinated Pesticides.
4.5 The Enantioselective Toxicities of Phosphorous Pesticides.
4.6 The Enantioselective Toxicities of Polyaromatic Hydrocarbons (PAHs).
4.7 The Enantioselective Toxicities of Other Xenobiotics.
4.8 The Enantioselective Toxicities of Drugs and Pharmaceuticals.
4.9 Conclusions.
References.
5 Sample Preparation.
5.1 Introduction.
5.2 Sampling.
5.3 Filtration.
5.4 Homogenization.
5.5 Extraction.
5.6 Membrane Methods in Sample Preparation.
5.7 Clean-up.
5.8 Pre-concentration.
5.9 Conclusions.
References.
6 The Analysis of Chiral Pollutants by Gas Chromatography.
6.1 Introduction.
6.2 Chiral Selectors.
6.3 Applications.
6.4 The Optimization of GC Conditions.
6.5 The Reverse Elution Order.
6.6 Errors and Problems in Enantioresolution.
6.7 The Derivatization of Chiral Environmental Pollutants.
6.8 Mechanisms of Chiral Resolution.
6.9 Conclusions.
References.
7 The Analysis of Chiral Pollutants by High Performance Liquid Chromatography.
7.1 Introduction.
7.2 Chiral Selectors.
7.3 Applications.
7.4 The Optimization of HPLC Conditions.
7.5 Detection.
7.6 Chiral Recognition Mechanisms.
7.7 Conclusions.
References.
8 The Analysis of Chiral Pollutants byMicellar Electrokinetic, Capillary Electrochromatographic, Supercritical Fluid and Thin Layer Chromatographic Techniques.
8.1 Introduction.
8.2 Chiral Selectors.
8.3 Micellar Electrokinetic Chromatography (MEKC).
8.4 Capillary Electrochromatography (CEC).
8.5 Supercritical Fluid Chromatography (SFC).
8.6 Thin Layer Chromatography (TLC).
8.7 LC versus GC.
8.8 Conclusions.
References.
9 The Analysis of Chiral Environmental Pollutants by Capillary Electrophoresis.
9.1 Introduction.
9.2 Chiral Selectors.
9.3 Applications.
9.4 The Optimization of CE Conditions.
9.5 Detection.
9.6 Validation of Methods.
9.7 Mechanisms of Chiral Resolution.
9.8 CE versus HPLC.
9.9 Conclusions.
References.
10 Perspectives on the Analysis of Chiral Pollutants.
10.1 Introduction.
10.2 Regulations on Chirality in the USA.
10.3 Regulations on Chirality in Europe.
10.4 Regulations on Chirality in Japan.
10.5 Regulations on Chirality in Other Countries.
10.6 The Capabilities of Chiral Analysis Technologies.
10.7 The Large-scale Production of Pure Enantiomers.
10.8 The Impact of Chirality on Economic Growth.
10.9 Conclusions.
References.
Index.
