Describes the role of chromatography in the development of new drugs. Features chapters on the analysis of natural and recombinant pharmaceutical products. Covers new techniques such as capillary electrophoresis and a number of hyphenated techniques that combine liquid chromatography or gas chromatography with mass spectrometry. Describes such applications as impurity analysis, chiral separations, metabolic studies, robotics, and support of biotechnology products. Also describes trace and ultratrace analyses in a variety of matrices.
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Höhe: 225 mm
Breite: 152 mm
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ISBN-13
978-0-8412-2498-8 (9780841224988)
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Schweitzer Klassifikation
Chromatography and Pharmaceutical Analysis; Chromatography and New Drug Development; Alternate Strategies for Analysis of Pharmaceuticals; Ruggedness of Impurity Determinations in Pharmaceuticals: High-Performance Liquid Chromatography Analysis with Ultraviolet Detection; High-Performance Liquid Chromatography in Pharmaceutical Development of Antibiotic Products; Gas Chromatography and Pharmaceutical Analyses; Gas Chromatography and Mass Spectrometry of Erythrina Alkaloids from the Foliage of Genetic Clones of Three Erythrina Species; Developing Stereoselective High-Performance Liquid Chromatographic Assays for Pharmacokinetic Studies; Direct Enantiomeric Separation and Analysis of Some Aromatase Inhibitors on Cellulose-Based Chiral Stationary Phases; Chromatographic Analysis of Host-Cell Protein Impurities in Pharmaceuticals Derived from Recombinant DNA; Binding Proteins in Development of Online Postcolumn Reaction Detection Systems for Liquid Chromatography; Determination of a New Oral Cephalosporin in Biological Fluids: Liquid Chromatographic, Ultraviolet, and Mass Spectrometric Methods; Drugs and Metabolites in Biological Fluids: Automated Analysis by Laboratory Robotics; Preparative Separations of Glycerophospholipids by High-Performance Liquid Chromatography; Small-Molecule Pharmaceutical Separations by Capillary Electrophoresis: Method Development and Manipulation of Selectivity
