A definitive reference for researchers working on problems involving chirality. Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques. Four chapters provide a detailed review of the commonly used columns: brush type, cyclodextrin, polysaccaride carbonate, and protein. Many of the papers focus on HPLC, a technique which is also ideally suited
for large scale preparation of optical isomers. In addition, the volume provides significant discussion on the use of chiral discriminators or selectors.
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Verlagsort
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Höhe: 235 mm
Breite: 156 mm
Dicke: 23 mm
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ISBN-13
978-0-8412-2116-1 (9780841221161)
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Schweitzer Klassifikation
Chiral Separations: Overview ; Analytical Criteria for Chiral High-Pressure Liquid Chromatography ; Commercially Available Brush-Type Chiral Selectors for the Direct Resolution of Enantiomers ; Chiral Separations Using Native and Functionalized Cyclodextrin-Bonded Stationary Phases in High-Pressure Liquid Chromatography ; Chromatographical Optical Resolution on Polysaccharide Carbamate Phases ; Protein Column-Based Chiral Reversed-Phase Liquid Chromatography ; Optimization of Chiral Separations on Silica-Bonded *a[1-Acid Glycoprotein by Mobile Phase Additives ; Chiral Recognition on Biopolymer-Based High-Pressure Liquid Chromatographic Chiral Stationary Phases: A Case for Multiple Interaction Sites ; Chiral Separations and Modes of Association of Hydrogen-Bonding Molecules ; Liquid Chromatographical Separation of Enantiomers by Hydrogen-Bond Association ; High-Pressure Liquid Chromatographic Resolution of Optical Isomers: Influence of Mobil and pi-Donor Chiral Stationary Phases ; Direct Stereochemical High-Pressure Liquid Chromatographic Separation of Aminoglutethimide and Its Major Metbolite: Its Applications to Biological Fluids ; Amino Acid Racemization: A Tool for Dating?
