The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric
composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.
Rezensionen / Stimmen
" very timely ... This is a highly recommended volume for those wishing to learn about chiral chromatography from a practical viewpoint ... the book should be in every library" Process Research and Development Journal
Sprache
Verlagsort
Zielgruppe
Illustrationen
Maße
Höhe: 243 mm
Breite: 162 mm
Dicke: 17 mm
Gewicht
ISBN-13
978-0-8412-3631-8 (9780841236318)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Klassifikation
Chapter 1. An overview ; Chirality and biological activity ; Chiral separations ; Chiral stationary phases ; Modern CSP design ; Preparative separations ; Regulatory perspectives ; Chapter 2. Perspectives on Evaluation of Stereoisomers as Drug Candidates ; Marketing status of single isomers ; Development of single enantiomers ; Pharmacokinetics ; Detoxification ; Stability ; Industrial perspectives ; Regulatory guidelines ; Chapter 3. Review of Stereochemistry ; Brief history ; Stereoisomerism ; Classification ; Nomenclature ; Resolution ; Enantiopurity ; Determination of absolute configuration ; Chapter 4. Separation Methods ; Thin layer chromatography ; Gas chromatography ; High pressure liquid chromatography ; Supercritical fluid chromatography ; Capillary electrophoresis ; Chapter 5. Detection Methods ; Detectors for TLC ; Detectors for GC ; Detectors for HPLC ; Specific detectors for chiral compounds ; Chapter 6. Desirable Features of Chiral Stationary Phases ; Desirable features ; Types of CSPs ; Comparison of various CSPs ; Chapter 7. Understanding Chiral Chromatography ; Enantioselective interactions ; Chromatographic enantioselectivity ; Inclusion ; Transition metal complexes ; Separations on protein columns ; Molecular modeling ; Chapter 8. Method Development ; Stereoisomeric Interactions ; Chromatographic methods ; Chromatographic methods ; Modes of separation in HPLC ; Chromatography of diastereomeric derivatives ; Enantiomeric resolution using chiral mobile-phase additives ; Enantiomeric resolution using chiral stationary phases ; Computerized methods ; Chapter 9. Preparative Separations ; Displacement chromatography ; Elution chromatography ; Chapter 10. Method Selection and Selected Applications ; Where to start? ; Study the molecule ; Which method to use? ; High pressure liquid chromatography ; Gas chromatography ; Supercritical fluid chromatography (SFC) ; Capillary electrophoresis (CE) ; Comparative separations
