Organic Synthesis
Strategy and Control
1st Edition
Published on 20. May 2013
920 pages
978-1-118-68144-2 (ISBN)
Description
Organic Synthesis: Strategy and Control is thelong-awaited sequel to Stuart Warren's bestseller OrganicSynthesis: The Disconnection Approach, which looked at theplanning behind the synthesis of compounds. This unique booknow provides a comprehensive, practical account of the key conceptsinvolved in synthesising compounds and focuses on putting theplanning into practice.
The two themes of the book are strategy andcontrol: solving problems either by finding an alternativestrategy or by controlling any established strategy to make itwork. The book is divided into five sections that deal withselectivity, carbon-carbon single bonds, carbon-carbon doublebonds, stereochemistry and functional group strategy.
* A comprehensive, practical account of the key concepts involvedin synthesising compounds
* Takes a mechanistic approach, which explains reactions andgives guidelines on how reactions might behave in differentsituations
* Focuses on reactions that really work rather than those withlimited application
* Contains extensive, up-to-date references in each chapter
Students and professional chemists familiar with OrganicSynthesis: The Disconnection Approach will enjoy the leap intoa book designed for chemists at the coalface of organicsynthesis.
Reviews / Votes
This is a book which will change the way you think about makingmolecules. (Chemistry World, July 2008) The authors can be commended on producing a really useful andenjoyable new book on Organic Synthesis. (Reviews, June2008) "The authors have spent approximately ten years putting thisexcellent book together, and their hard work has paid off."(Journal of Chemical Education, May 2008) "Of interest to the experienced practitioner looking to broaden(or reawaken) awareness of the remarkable diversity of availablesynthetic transformations"(Journal of Medicinal Chemistry,2008)More details
Other editions
Additional editions
Book
04/2007
Wiley
€69.50
Shipment within 10-20 days
Book
04/2007
1st Edition
Wiley
€173.50
Shipment within 10-20 days
Persons
Paul Wyatt, Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK and Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.
Content
A: Introduction: Selectivity.
1. Planning Organic Syntheses: Tactics, Strategy, andControl.
2. Chemoselectivity.
3. Regioselectivity: Controlled Aldol Reactions.
4. Stereoselectivity: Stereoselective AldolReactions.
5. Alternative Strategies for Enone Synthesis.
6. Choosing a Strategy : The Synthesis ofcyclopentenones.
B: Making Carbon-Carbon Bonds.
7. The Ortho Strategy for Aromatic Compounds.
8. delta-Complexes of Metals.
9. Controlling the Michael Reaction.
10. Specific Enol Equivalents.
11. Extended Enolates.
12. Allyl Anions.
13. Homoenolates.
14. Acyl Anion Equivalents.
C: Carbon-Carbon Double Bonds.
15. Synthesis of Double Bonds of DefinedStereochemistry.
16. Stereo-Controlled Vinyl Anion Equivalents.
17. Electrophilic Attack on Alkenes.
18. Vinyl Cations: Palladium-Catalysed C-CCoupling.
19. Allyl Alcohols: Allyl Cation Equivalents (andMore).
D: Stereochemistry.
20. Control of Stereochemistry -- Introduction.
21 Controlling Relative Stereochemistry.
22. Resolution.
23. The Chiral Pool.
24. Asymmetric Induction I: Reagent-Based Strategy.
25. Asymmetric Induction II: Asymmetric Catalysis:Formation of C-O and C-N Bonds.
26. Asymmetric Induction III: Asymmetric Catalysis:Formation of C-H and C-C Bonds.
27. Asymmetric Induction IV: Substrate-BasedStrategy.
28. Kinetic Resolution.
29. Enzymes: Biological Methods in AsymmetricSynthesis.
30. New Chiral Centres from Old.
31. Strategy of Asymmetric Synthesis.
E: Functional Group Strategy.
32. Functionalisation of Pyridine.
33. Oxidation of Aromatic Compounds, Enols andEnolates.
34. Functionality and Pericyclic Reactions: NitrogenHeterocycles by Cycloadditions and Sigmatropic Rearrangements.
35. Synthesis and Chemistry of Azoles and otherHeterocycles with Two or more Heteroatoms.
36. Tandem Organic Reactions.
General References.
Index.
