Organic Synthesis
Strategy and Control
1st Edition
Published on 20. April 2007
Book
Hardback
928 pages
978-0-471-48940-5 (ISBN)
Description
Organic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds.
The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.
The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.
A comprehensive, practical account of the key concepts involved in synthesising compounds.
Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations.
Focuses on reactions that really work rather than those with limited application.
Extensive, up-to-date references in each chapter.
Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.
The two themes of this new book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.
The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.
A comprehensive, practical account of the key concepts involved in synthesising compounds.
Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations.
Focuses on reactions that really work rather than those with limited application.
Extensive, up-to-date references in each chapter.
Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.
Reviews / Votes
"The authors can be commended on producing a really useful and enjoyable new book on Organic Synthesis! ... .Rewarding to read." (The Higher Education Academy Physical Sciences Centre, June 2008)More details
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Product notice
sewn/stitched
Paper over boards
Dimensions
Height: 249 mm
Width: 193 mm
Thickness: 54 mm
Weight
1869 gr
ISBN-13
978-0-471-48940-5 (9780471489405)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
05/2013
1st Edition
Wiley
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E-Book
04/2007
Wiley
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Available for download
Book
04/2007
Wiley
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Persons
Paul Wyatt, Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK.
Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.
Stuart Warren, Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK.
Content
Preface.
A: Introduction: Selectivity.
1. Planning Organic Syntheses: Tactics, Strategy, andControl.
2. Chemoselectivity.
3. Regioselectivity: Controlled Aldol Reactions.
4. Stereoselectivity: Stereoselective AldolReactions.
5. Alternative Strategies for Enone Synthesis.
6. Choosing a Strategy : The Synthesis ofcyclopentenones.
B: Making Carbon-Carbon Bonds.
7. The Ortho Strategy for Aromatic Compounds.
8. delta-Complexes of Metals.
9. Controlling the Michael Reaction.
10. Specific Enol Equivalents.
11. Extended Enolates.
12. Allyl Anions.
13. Homoenolates.
14. Acyl Anion Equivalents.
C: Carbon-Carbon Double Bonds.
15. Synthesis of Double Bonds of DefinedStereochemistry.
16. Stereo-Controlled Vinyl Anion Equivalents.
17. Electrophilic Attack on Alkenes.
18. Vinyl Cations: Palladium-Catalysed C-CCoupling.
19. Allyl Alcohols: Allyl Cation Equivalents (andMore).
D: Stereochemistry.
20. Control of Stereochemistry -- Introduction.
21 Controlling Relative Stereochemistry.
22. Resolution.
23. The Chiral Pool.
24. Asymmetric Induction I: Reagent-Based Strategy.
25. Asymmetric Induction II: Asymmetric Catalysis:Formation of C-O and C-N Bonds.
26. Asymmetric Induction III: Asymmetric Catalysis:Formation of C-H and C-C Bonds.
27. Asymmetric Induction IV: Substrate-BasedStrategy.
28. Kinetic Resolution.
29. Enzymes: Biological Methods in AsymmetricSynthesis.
30. New Chiral Centres from Old --Enantiomerically Pure Compounds & SophisticatedSyntheses.
31. Strategy of Asymmetric Synthesis.
E: Functional Group Strategy.
32. Functionalisation of Pyridine.
33. Oxidation of Aromatic Compounds, Enols andEnolates.
34. Functionality and Pericyclic Reactions: NitrogenHeterocycles by Cycloadditions and Sigmatropic Rearrangements.
35. Synthesis and Chemistry of Azoles and otherHeterocycles with Two or more Heteroatoms.
36. Tandem Organic Reactions.
General References.
Index.
A: Introduction: Selectivity.
1. Planning Organic Syntheses: Tactics, Strategy, andControl.
2. Chemoselectivity.
3. Regioselectivity: Controlled Aldol Reactions.
4. Stereoselectivity: Stereoselective AldolReactions.
5. Alternative Strategies for Enone Synthesis.
6. Choosing a Strategy : The Synthesis ofcyclopentenones.
B: Making Carbon-Carbon Bonds.
7. The Ortho Strategy for Aromatic Compounds.
8. delta-Complexes of Metals.
9. Controlling the Michael Reaction.
10. Specific Enol Equivalents.
11. Extended Enolates.
12. Allyl Anions.
13. Homoenolates.
14. Acyl Anion Equivalents.
C: Carbon-Carbon Double Bonds.
15. Synthesis of Double Bonds of DefinedStereochemistry.
16. Stereo-Controlled Vinyl Anion Equivalents.
17. Electrophilic Attack on Alkenes.
18. Vinyl Cations: Palladium-Catalysed C-CCoupling.
19. Allyl Alcohols: Allyl Cation Equivalents (andMore).
D: Stereochemistry.
20. Control of Stereochemistry -- Introduction.
21 Controlling Relative Stereochemistry.
22. Resolution.
23. The Chiral Pool.
24. Asymmetric Induction I: Reagent-Based Strategy.
25. Asymmetric Induction II: Asymmetric Catalysis:Formation of C-O and C-N Bonds.
26. Asymmetric Induction III: Asymmetric Catalysis:Formation of C-H and C-C Bonds.
27. Asymmetric Induction IV: Substrate-BasedStrategy.
28. Kinetic Resolution.
29. Enzymes: Biological Methods in AsymmetricSynthesis.
30. New Chiral Centres from Old --Enantiomerically Pure Compounds & SophisticatedSyntheses.
31. Strategy of Asymmetric Synthesis.
E: Functional Group Strategy.
32. Functionalisation of Pyridine.
33. Oxidation of Aromatic Compounds, Enols andEnolates.
34. Functionality and Pericyclic Reactions: NitrogenHeterocycles by Cycloadditions and Sigmatropic Rearrangements.
35. Synthesis and Chemistry of Azoles and otherHeterocycles with Two or more Heteroatoms.
36. Tandem Organic Reactions.
General References.
Index.