Handbook for Chemical Process Research and Development
1st Edition
Published on 27. September 2016
Book
Hardback
810 pages
978-1-4987-6799-6 (ISBN)
Description
The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.
More details
Language
English
Place of publication
Portland
United States
Publishing group
Taylor & Francis Inc
Target group
College/higher education
Professional and scholarly
Illustrations
1446 s/w Abbildungen, 20 s/w Tabellen
20 Tables, black and white; 1446 Illustrations, black and white
Dimensions
Height: 254 mm
Width: 178 mm
Weight
1655 gr
ISBN-13
978-1-4987-6799-6 (9781498767996)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Book
03/2023
2nd Edition
CRC Press
€275.09
Shipment within 10-20 days
Additional editions
Book
06/2020
1st Edition
CRC Press
€55.70
Article exhausted; check for reprint
Person
Dr. Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of the American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow at the Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate Professor at the Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (now the Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Senior Research Associate in the Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Early in 2001, Dr. Zhao moved into the private sector to become a process chemist in the pharmaceutical industry in the United States. He is the author of numerous journal articles and holds several patents.
Content
Chapter 1: Modes Of Reagent Addition - Control of Impurity Formation
Chapter 2: Process Optimization
Chapter 3: Hazardous Reactions
Chapter 4: Catalytic Reactions
Chapter 5: Grignard Reagent And Related Reactions
Chapter 6: Challenging Reaction Intermediates
Chapter 7: Protecting Groups
Chapter 8: Reaction Solvents
Chapter 9: Base Reagent Selection
Chapter 10: Reagents For Amide Formation
Chapter 11: Various Reagent Surrogates
Chapter 12: Telescope Approach
Chapter 13: Stereochemistry
Chapter 14: Design Of New Synthetic Route
Chapter 15: Reaction Workup
Chapter 16: Pharmaceutical Salts
Chapter 17: Solid Form
Chapter 2: Process Optimization
Chapter 3: Hazardous Reactions
Chapter 4: Catalytic Reactions
Chapter 5: Grignard Reagent And Related Reactions
Chapter 6: Challenging Reaction Intermediates
Chapter 7: Protecting Groups
Chapter 8: Reaction Solvents
Chapter 9: Base Reagent Selection
Chapter 10: Reagents For Amide Formation
Chapter 11: Various Reagent Surrogates
Chapter 12: Telescope Approach
Chapter 13: Stereochemistry
Chapter 14: Design Of New Synthetic Route
Chapter 15: Reaction Workup
Chapter 16: Pharmaceutical Salts
Chapter 17: Solid Form