Handbook for Chemical Process Research and Development, Second Edition
Wenyi Zhao(Author)
CRC Press
2nd Edition
Published on 21. March 2023
Book
Hardback
866 pages
978-1-032-25927-7 (ISBN)
Description
This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies.
Features:
This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
Promotes an industrial mindset concerning safety and commercial viability when developing methods.
The author discusses development strategies with case studies and experimental procedures.
Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
Addresses more common process issues such as safety, cost, robustness, and environmental impact.
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
Features:
This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner.
Promotes an industrial mindset concerning safety and commercial viability when developing methods.
The author discusses development strategies with case studies and experimental procedures.
Focuses on mechanism-guided process development which provides readers with practical strategies and approaches.
Addresses more common process issues such as safety, cost, robustness, and environmental impact.
This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.
More details
Edition
2nd edition
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
College/higher education
Professional and scholarly
Academic, Postgraduate, Professional, and Undergraduate Advanced
Illustrations
2 farbige Zeichnungen, 642 s/w Abbildungen, 2 farbige Abbildungen, 642 s/w Zeichnungen, 24 s/w Tabellen
24 Tables, black and white; 2 Line drawings, color; 642 Line drawings, black and white; 2 Illustrations, color; 642 Illustrations, black and white
Dimensions
Height: 254 mm
Width: 178 mm
Weight
1880 gr
ISBN-13
978-1-032-25927-7 (9781032259277)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

Book
10/2024
2nd Edition
CRC Press
€103.70
Shipment within 10-20 days

E-Book
03/2023
2nd Edition
CRC Press
€96.49
Available for download

E-Book
03/2023
2nd Edition
CRC Press
€96.49
Available for download
Previous edition

Book
09/2016
1st Edition
Productivity Press
€267.41
Article exhausted; check for reprint
Person
Dr Wenyi Zhao, Senior Research Scientist (Process Chemistry), Member of American Chemical Society. 1980-1990: Ph.D., Organic/Physical Organic Chemistry, Nanjing University, China. 1990-1992: Postdoctoral fellow in Institute of Chemistry, Chinese Academy of Sciences, Beijing. 1992-1995: Associate professor in Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing (Now becomes Institute of Chemistry, Chinese Academy of Sciences, Beijing). 1995-2001: Sr. research associate in Department of Chemistry, Texas Tech University, Lubbock, Texas 2001 - 2005. Dr Wenyi Zhao then moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.
Content
1. Reaction solvent selection
2. Reagent selection
3. Various reagent surrogates
4. Modes of reagent addition -control of impurity formation
5. Process optimization with additives
6. Process optimization of catalytic reactions
7. Process optimization of problematic reactions
8. Hazards of oxidation and reduction reactions
9. Other hazardous reactions
10. Hazardous reagents
11. Grignard reagent and related reactions
12. Challenging reaction intermediates
13. Protecting groups
14. Telescope approach
15. Design of new synthetic route
16. Stereochemistry
17. Various quenching strategies
18. Various isolation and purification strategies
19. Methods for residual metal removal
20. Methods for impurity removal
21. Pharmaceutical salts
22. Solid form
2. Reagent selection
3. Various reagent surrogates
4. Modes of reagent addition -control of impurity formation
5. Process optimization with additives
6. Process optimization of catalytic reactions
7. Process optimization of problematic reactions
8. Hazards of oxidation and reduction reactions
9. Other hazardous reactions
10. Hazardous reagents
11. Grignard reagent and related reactions
12. Challenging reaction intermediates
13. Protecting groups
14. Telescope approach
15. Design of new synthetic route
16. Stereochemistry
17. Various quenching strategies
18. Various isolation and purification strategies
19. Methods for residual metal removal
20. Methods for impurity removal
21. Pharmaceutical salts
22. Solid form