Organic Synthesis
The Disconnection Approach
2nd Edition
Published on 21. November 2008
Book
Hardback
342 pages
978-0-470-71237-5 (ISBN)
Description
Organic Synthesis: The Disconnection Approach is the long-awaited second edition of a classic textbook; the first to provide a structured course in retrosynthesis- now an important technique used by generations of organic chemists. Now fully revised and updated with a modern look, 25 years of advances in organic synthesis are reflected with the addition of new examples and synthetic pathways. Additional material has been added to take the student to the level required by the bestselling sequel, "Organic Synthesis: Strategy and Control" and the later chapters have extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.
Reviews / Votes
?The authors have succeeded admirably in the updating of a classic in the pedagogy of organic chemistry.? ( Journal of Medicinal Chemistry , August 2009) ?This book is suitable for advanced undergraduate students, researchers and professional chemists. Both the writing and the diagrams are simple and clear.? ( Reviews, May 2009)More details
Other editions
Additional editions
E-Book
03/2013
2nd Edition
Wiley
€37.99
Available for download
E-Book
08/2011
2nd Edition
Wiley
€37.99
Available for download
Book
11/2008
2nd Edition
Wiley
€45.00
Available immediately
Persons
Dr Stuart Warren, Department of Chemistry, University of Cambridge, UK
Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP).
Dr Paul Wyatt, School of Chemistry, University of Bristol, UK
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control.
Dr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley), Organic Synthesis: Strategy and Control (Wiley) and Organic Chemistry (OUP).
Dr Paul Wyatt, School of Chemistry, University of Bristol, UK
Dr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning. He is co-author, with Warren, of Organic Synthesis: Strategy and Control.
Content
1. Introduction: Planning Organic Syntheses..
2. Synthons and Reagents: Aromatic Compounds.
3. Strategy I: The Order of Events.
4. One-Group C-X Disconnections.
5. Chemoselectivity.
6. Two-Group C-X Disconnections.
7. Strategy III.
8. Amine Synthesis.
9. Protecting Groups.
10. One Group C-C Disconnections I: Alcohols.
11. General Strategy A: Choosing Disconnections.
12. Stereoselectivity A.
13. One Group C-C Disconnections II: Carbonyl Compounds.
14. Regioselectivity.
15. Alkene Synthesis.
16. Strategy VII: Use of Acetylenes.
17. Diels-Alder.
18. Strategy VIII: Carbonyl Condensations.
19. 1,3-diCO Compounds.
20. Control in C=O Condensations.
21. 1,5-diCO Compounds.
22. Nitro Groups.
23. 1,2-diCO Compounds.
24. Radicals.
25. 1,4-diCO Compounds.
26. Reconnection.
27. 1,6-diCO Compounds.
28. Strategy of C=O Disconnections.
29. Saturated Heterocycles.
30. Cyclopropanes.
31. Rearrangements.
32. Four-Membered Rings.
33. Ketenes.
34. Five-Membered Rings.
35. Pericyclic Reactions.
36. Six-Membered Rings.
37. Strategy of Ring Synthesis.
38. Stereoselectivity B.
39. Aromatic Heterocycles.
40: Advanced Strategy.