Organic Synthesis

One approach to organic synthesis is retrosynthetic analysis. Withthis approach a chemist will start with the structure of theirtarget molecule and progressively cut bonds to create simplermolecules. Reversing this process gives a synthetic route to thetarget molecule from simpler starting materials. This"disconnection" approach to synthesis is now afundamental part of every organic synthesis course. Organic Synthesis: The Disconnection Approach,2nd Edition introduces this important technique,to help students to design their own organic syntheses. There areforty chapters: those on the synthesis of given types of moleculesalternate with strategy chapters in which the methods just learntare placed in a wider context. The synthesis chapters cover manyways of making each type of molecule starting with simple aromaticand aliphatic compounds with one functional group and progressingto molecules with many functional groups. The strategy chapterscover questions of selectivity, protection, stereochemistry, anddevelop more advanced thinking via reagents specifically designedfor difficult problems. Examples are drawn from pharmaceuticals, agrochemicals, naturalproducts, pheromones, perfumery and flavouring compounds,dyestuffs, monomers, and intermediates used in more advancedsynthetic work. Reasons for wishing to synthesise each compound aregiven. This second edition has been fully revised and updated with amodern look. Recent examples and techniques are included andillustrated additional material has been added to take the studentto the level required by the sequel, "Organic Synthesis:Strategy and Control". Several chapters contain extensive new material based on coursesthat the authors give to chemists in the pharmaceuticalindustry. Organic Synthesis: The Disconnection Approach, 2ndedition provides a full course in retrosynthetic analysis forchemistry and biochemistry students and a refresher for organicchemists working in industry and academia.