Healthcare Analytics

LIST OF CONTRIBUTORS xvii PREFACE xxi PART I ADVANCES IN BIOMEDICAL AND HEALTH INFORMATICS 1 1 Recent Development in Methodology for Gene Network Problems and Inferences 3 Sung W. Han and Hua Zhong 1.1 Introduction 3 1.2 Background 5 1.3 Genetic Data Available 7 1.4 Methodology 7 1.5 Search Algorithm 13 1.6 PC Algorithm 15 1.7 Application/Case Studies 16 1.8 Discussion 23 1.9 Other Useful Softwares 23 Acknowledgments 24 References 24 2 Biomedical Analytics and Morphoproteomics: An Integrative Approach for Medical Decision Making for Recurrent or Refractory Cancers 31 Mary F. McGuire and Robert E. Brown 2.1 Introduction 31 2.2 Background 32 2.3 Methodology 37 2.4 Case Studies 46 2.5 Discussion 51 2.6 Conclusions 52 Acknowledgments 53 References 53 3 Characterization and Monitoring of Nonlinear Dynamics and Chaos in Complex Physiological Systems 59 Hui Yang, Yun Chen, and Fabio Leonelli 3.1 Introduction 59 3.2 Background 61 3.3 Sensor-Based Characterization and Modeling of Nonlinear Dynamics 65 3.4 Healthcare Applications 80 3.5 Summary 88 Acknowledgments 90 References 90 4 Statistical Modeling of Electrocardiography Signal for Subject Monitoring and Diagnosis 95 Lili Chen, Changyue Song, and Xi Zhang 4.1 Introduction 95 4.2 Basic Elements of ECG 96 4.3 Statistical Modeling of ECG for Disease Diagnosis 99 4.4 An Example: Detection of Obstructive Sleep Apnea from a Single ECG Lead 115 4.5 Materials and Methods 115 4.6 Results 118 4.7 Conclusions and Discussions 121 4.8 Conclusion 121 References 121 5 Modeling and Simulation of Measurement Uncertainty in Clinical Laboratories 127 Varun Ramamohan, James T. Abbott, and Yuehwern Yih 5.1 Introduction 127 5.2 Background and Literature Review 129 5.3 Model Development Guidelines 138 5.4 Implementation of Guidelines: Enzyme Assay Uncertainty Model 141 5.5 Discussion and Conclusions 152 References 154 6 Predictive Analytics: Classification in Medicine and Biology 159 Eva K. Lee 6.1 Introduction 159 6.2 Background 161 6.3 Machine Learning with Discrete Support Vector Machine Predictive Models 163 6.4 Applying DAMIP to Real-World Applications 170 6.5 Summary and Conclusion 182 Acknowledgments 183 References 183 7 Predictive Modeling in Radiation Oncology 189 Hao Zhang, Robert Meyer, Leyuan Shi, Wei Lu, and Warren D'Souza 7.1 Introduction 189 7.2 Tutorials of Predictive Modeling Techniques 191 7.3 Review of Recent Predictive Modeling Applications in Radiation Oncology 194 7.4 Modeling Pathologic Response of Esophageal Cancer to Chemoradiotherapy 199 7.5 Modeling Clinical Complications after Radiation Therapy 205 7.6 Modeling Tumor Motion with Respiratory Surrogates 211 7.7 Conclusion 215 References 215 8 Mathematical Modeling of Innate Immunity Responses of Sepsis: Modeling and Computational Studies 221 Chih-Hang J. Wu, Zhenshen Shi, David Ben-Arieh, and Steven Q. Simpson 8.1 Background 221 8.2 System Dynamic Mathematical Model (SDMM) 223 8.3 Pathogen Strain Selection 224 8.4 Mathematical Models of Innate Immunity of Air 239 8.5 Discussion 247 8.6 Conclusion 254 References 254 PART II ANALYTICS FOR HEALTHCARE DELIVERY 299 9 Systems Analytics: Modeling and Optimizing ClinicWorkflow and Patient Care 301 Eva K. Lee, Hany Y. Atallah, Michael D. Wright, Calvin Thomas IV, Eleanor T. Post, Daniel T. Wu, and Leon L. Haley Jr 9.1 Introduction 302 9.2 Background 304 9.3 Challenges and Objectives 305 9.4 Methods and Design of Study 306 9.5 Computational Results, Implementation, and ED Performance Comparison 323 9.6 Benefits and Impacts 330 9.7 Scientific Advances 335 Acknowledgments 336 References 337 10 A Multiobjective Simulation Optimization of the Macrolevel Patient Flow Distribution 341 Yunzhe Qiu and Jie Song 10.1 Introduction 341 10.2 Literature Review 343 10.3 Problem Description and Modeling 346 10.4 Methodology 350 10.5 Case Study: Adjusting Patient Flow for a Two-Level Healthcare System Centered on the Puth 354 10.6 Conclusions and the Future Work 367 Acknowledgments 368 References 369 11 Analysis of Resource Intensive Activity Volumes in us Hospitals 373 Shivon Boodhoo and Sanchoy Das 11.1 Introduction 373 11.2 Structural Classification of Hospitals 375 11.3 Productivity Analysis of Hospitals 377 11.4 Resource and Activity Database for us Hospitals 379 11.5 Activity-Based Modeling of Hospital Operations 382 11.6 Resource use Profile of Hospitals from HUC Activity Data 389 11.7 Summ