Healthcare Analytics

LIST OF CONTRIBUTORS xvii PREFACE xxi PART I ADVANCES IN BIOMEDICAL AND HEALTH INFORMATICS 1 1 Recent Development in Methodology for Gene Network Problems and Inferences 3 Sung W. Han and Hua Zhong 1.1 Introduction 3 1.2 Background 5 1.3 Genetic Data Available 7 1.4 Methodology 7 1.5 Search Algorithm 13 1.6 PC Algorithm 15 1.7 Application/Case Studies 16 1.8 Discussion 23 1.9 Other Useful Softwares 23 Acknowledgments 24 References 24 2 Biomedical Analytics and Morphoproteomics: An Integrative Approach for Medical Decision Making for Recurrent or Refractory Cancers 31 Mary F. McGuire and Robert E. Brown 2.1 Introduction 31 2.2 Background 32 2.3 Methodology 37 2.4 Case Studies 46 2.5 Discussion 51 2.6 Conclusions 52 Acknowledgments 53 References 53 3 Characterization and Monitoring of Nonlinear Dynamics and Chaos in Complex Physiological Systems 59 Hui Yang, Yun Chen, and Fabio Leonelli 3.1 Introduction 59 3.2 Background 61 3.3 Sensor-Based Characterization and Modeling of Nonlinear Dynamics 65 3.4 Healthcare Applications 80 3.5 Summary 88 Acknowledgments 90 References 90 4 Statistical Modeling of Electrocardiography Signal for Subject Monitoring and Diagnosis 95 Lili Chen, Changyue Song, and Xi Zhang 4.1 Introduction 95 4.2 Basic Elements of ECG 96 4.3 Statistical Modeling of ECG for Disease Diagnosis 99 4.4 An Example: Detection of Obstructive Sleep Apnea from a Single ECG Lead 115 4.5 Materials and Methods 115 4.6 Results 118 4.7 Conclusions and Discussions 121 References 121 5 Modeling and Simulation of Measurement Uncertainty in Clinical Laboratories 127 Varun Ramamohan, James T. Abbott, and Yuehwern Yih 5.1 Introduction 127 5.2 Background and Literature Review 129 5.3 Model Development Guidelines 138 5.4 Implementation of Guidelines: Enzyme Assay Uncertainty Model 141 5.5 Discussion and Conclusions 152 References 154 6 Predictive Analytics: Classification in Medicine and Biology 159 Eva K. Lee 6.1 Introduction 159 6.2 Background 161 6.3 Machine Learning with Discrete Support Vector Machine Predictive Models 163 6.4 Applying DAMIP to Real-World Applications 170 6.5 Summary and Conclusion 182 Acknowledgments 183 References 183 7 Predictive Modeling in Radiation Oncology 189 Hao Zhang, Robert Meyer, Leyuan Shi, Wei Lu, and Warren D'Souza 7.1 Introduction 189 7.2 Tutorials of Predictive Modeling Techniques 191 7.3 Review of Recent Predictive Modeling Applications in Radiation Oncology 194 7.4 Modeling Pathologic Response of Esophageal Cancer to Chemoradiotherapy 199 7.5 Modeling Clinical Complications after Radiation Therapy 205 7.6 Modeling Tumor Motion with Respiratory Surrogates 211 7.7 Conclusion 215 References 215 8 Mathematical Modeling of Innate Immunity Responses of Sepsis: Modeling and Computational Studies 221 Chih-Hang J. Wu, Zhenshen Shi, David Ben-Arieh, and Steven Q. Simpson 8.1 Background 221 8.2 System Dynamic Mathematical Model (SDMM) 223 8.3 Pathogen Strain Selection 224 8.5 Discussion 247 8.6 Conclusion 254 References 254 PART II ANALYTICS FOR HEALTHCARE DELIVERY 261 9 Systems Analytics: Modeling and Optimizing Clinic Workflow and Patient Care 263 Eva K. Lee, Hany Y. Atallah, Michael D. Wright, Calvin Thomas IV, Eleanor T. Post, Daniel T. Wu, and Leon L. Haley Jr 9.1 Introduction 264 9.2 Background 266 9.3 Challenges and Objectives 267 9.4 Methods and Design of Study 268 9.5 Computational Results, Implementation, and ED Performance Comparison 285 9.6 Benefits and Impacts 292 9.7 Scientific Advances 297 Acknowledgments 298 References 299 10 A Multiobjective Simulation Optimization of the Macrolevel Patient Flow Distribution 303 Yunzhe Qiu and Jie Song 10.1 Introduction 303 10.2 Literature Review 305 10.3 Problem Description and Modeling 308 10.4 Methodology 312 10.5 Case Study: Adjusting Patient Flow for a Two-Level Healthcare System Centered on the Puth 316 10.6 Conclusions and the Future Work 329 Acknowledgments 330 References 331 11 Analysis of Resource Intensive Activity Volumes in US Hospitals 335 Shivon Boodhoo and Sanchoy Das 11.1 Introduction 335 11.2 Structural Classification of Hospitals 337 11.3 Productivity Analysis of Hospitals 339 11.4 Resource and Activity Database for US Hospitals 341 11.5 Activity-Based Modeling of Hospital Operations 344 11.6 Resource use Profile of Hospitals from HUC Activity Data 351 11.7 Summary 357 References 358 12 Discrete-Event Simulation for Primary Care Redesign: Review and a Case Study 361 Xiang Zhong, Molly Williams, Jingshan Li, Sally A. Kraft, and Jeffrey S. Sleeth 12.1 Introduction 361 12.2 Review of Relevant Literature 362 12.3 A Simulation Case Study at a Pediatric Clinic 369 12.4 What- If Analyses 376 12.5 Conclusions 382 References 382 13 Temporal and Spatiotemporal Models for Ambulance Demand 389 Zhengyi Zhou and David S. Matteson 13.1 Introduction 389 13.2 Temporal Ambulance Demand Estimation 391 13.3 Spatiotemporal Ambulance Demand Estimation 398 13.4 Conclusions 409 References 410 14 Mathematical Optimization and Simulation Analyses for Optimal Liver Allocation Boundaries 413 Naoru Koizumi, Monica Gentili, Rajesh Ganesan, Debasree DasGupta, Amit Patel, Chun-Hung Chen, Nigel Waters, and Keith Melancon 14.1 Introduction 414 14.2 Methods 416 14.3 Results 423 14.4 Conclusions 433 Acknowledgment 435 References 435 15 Predictive Analytics in 30-Day Hospital Readmissions for Heart Failure Patients 439 Si-Chi Chin, Rui Liu, and Senjuti B. Roy 15.1 Introduction 440 15.2 Analytics in Prediction Hospital Readmission Risk 441 15.3 Analytics in Recommending Intervention Strategies 447 15.4 Related Work 457 15.5 Conclusion 459 References 459 16 Heterogeneous Sensing and Predictive Modeling of Postoperative Outcomes 463 Yun Chen, Fabio Leonelli, and Hui Yang 16.1 Introduction 463 16.2 Research Background 466 16.3 Research Methodology 474 16.4 Materials and Experimental Design 491 16.5 Experimental Results 491 16.6 Discussion and Conclusions 498 Acknowledgments 499 References 499 17 Analyzing Patient-Physician Interaction in Consultation for Shared Decision Making 503 Thembi Mdluli, Joyatee Sarker, Carolina Vivas-Valencia, Nan Kong, and Cleveland G. Shields 17.1 Introduction 503 17.2 Literature Review 505 17.3 Our Recent Data Mining Studies 510 17.4 Future Directions 515 17.5 Concluding Remarks 519 References 520 18 The History and Modern Applications of Insurance Claims Data in Healthcare Research 523 Margrét V. Bjarndóttir, David Czerwinski, and Yihan Guan 18.1 Introduction 523 18.2 Healthcare Cost Predictions 531 18.3 Measuring Quality of Care 540 18.4 Conclusions 548 References 548 19 Understanding the Role of Social Media in Healthcare via Analytics: a Health Plan Perspective 555 Sinjini Mitra and Rema Padman 19.1 Introduction 555 19.2 Literature Review 556 19.3 Case Study Description 562 19.4 Research Methods and Analytics Tools 564 19.5 Results and Discussions 568 19.6 Conclusions 584 References 585 INDEX 589