Drug Delivery
Engineering Principles for Drug Therapy
1st Edition
Published on 15. March 2001
385 pages
978-0-19-802469-9 (ISBN)
Description
Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.
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04/2001
Oxford University Press Inc
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Content
- Intro
- Contents
- Part I: Introductory material
- 1 Introduction
- 1.1 Historical perspective
- 1.2 The aim and structure of this book
- 2 Drug administration and drug effectiveness
- 2.1 The state of the art
- 2.2 Two views of the future
- Summary
- Part II: Fundamentals
- 3 Diffusion and drug dispersion
- 3.1 Random walks
- 3.2 Equations for the diffusive flux (Fick's law)
- 3.3 Equations of mass conservation (Fick's second law)
- 3.4 Solutions to the diffusion equation with no solute elimination or generation
- 3.5 Solutions to the diffusion equation with solute binding and elimination
- 3.6 A few applications
- Summary
- 4 Diffusion in biological systems
- 4.1 Measurement of diffusion coefficients
- 4.2 Diffusion in water
- 4.3 Diffusion in polymer solutions and gels
- 4.4 Diffusion in the extracellular space
- 4.5 Diffusion with binding in tissues
- 4.6 Diffusion within cells
- 4.7 Diffusion and reaction
- Summary
- 5 Drug permeation through biological barriers
- 5.1 Mobility of lipids and proteins in the membrane
- 5.2 Permeation through lipid membranes
- 5.3 Permeation through porous membranes
- 5.4 Permeation is enhanced by membrane proteins
- 5.5 Permeation through cell layers
- Summary
- 6 Drug transport by fluid motion
- 6.1 Blood movement in the circulatory system
- 6.2 Interstitial fluid movement
- 6.3 Fluid movement in the lymphatic circulation
- 6.4 Fluid movement in the brain
- Summary
- 7 Pharmacokinetics of drug distribution
- 7.1 Compartmental models
- 7.2 Physiological models
- 7.3 Patterns of mixing in tissues and organs
- 7.4 The problem of scale
- Summary
- Part III: Drug delivery systems
- 8 Drug modification
- 8.1 Enhancing agent solubility
- 8.2 Enhancing agent stability
- 8.3 Regulating agent permeability
- 8.4 Drug targeting and drug valency
- Summary
- 9 Controlled drug delivery systems
- 9.1 Reservoir and transdermal delivery systems
- 9.2 Matrix delivery systems
- 9.3 Hydrogel delivery systems
- 9.4 Degradable delivery systems
- 9.5 Particulate delivery systems
- 9.6 Responsive delivery systems
- Summary
- 10 Case studies in drug delivery
- 10.1 Controlled delivery of systemic therapy
- 10.2 Implants for local drug delivery
- 10.3 Topically applied devices for controlled release
- 11 Postscript
- Appendix A: Overview of polymeric biomaterials
- A.1 Non-degradable polymers
- A.1.1 Silicone elastomers
- A.1.2 Poly[ethylene-co-(vinyl acetate)]
- A.1.3 Polyurethanes
- A.1.4 Other important polymers
- A.2 Biodegradable polymers
- A.2.1 Polyesters
- A.2.2 Copolymers of methyl vinyl ether and maleic anhydride
- A.2.3 Poly(ortho esters)
- A.2.4 Polyanhydrides
- A.2.5 Poly(amino acids)
- A.2.6 Phosphorus-containing polymers
- A.2.7 Polycarbonates and poly(iminocarbonates)
- A.2.8 Polydioxanone
- A.3 Water-soluble polymers
- A.3.1 Naturally occurring polymers
- A.3.2 Acrylates and acrylamides
- A.3.3 Poly(ethylene glycol)
- Appendix B: Useful data and nomenclature
- B.1 Physiological parameters
- B.2 Cardiovascular system
- B.3 Clinical chemistry
- B.4 Permeation and diffusion
- B.5 Protein properties
- B.6 Mathematical tables and functions
- B.7 Nomenclature
- Index
- A
- B
- C
- D
- E
- F
- G
- H
- I
- K
- L
- M
- N
- O
- P
- R
- S
- T
- V
- W
