Lung Cancer
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"With almost half of the revised and updated content beingbrand new, Lung Cancer, Fourth Edition, is an important and vitalresource for all medical professionals and students involved in thecare and treatment of those struck with this catastrophicillness." (Kingbook73's Medical Ebook and VideoCollection, 19 September 2014)More details
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Content
Contributors, viii
Preface, xiii
1 Smoking Prevention and Cessation, 1
Alexander V. Prokhorov and Karen Suchanek Hudmon
2 Lung Cancer Susceptibility and Risk Assessment Models, 25
Xifeng Wu, Xia Pu, and Jie Lin
3 Molecular Profiling, 48
Lauren Averett Byers
4 Somatic Genome Alterations in Human Lung Cancers, 67
Marcin Imielinski, Peter S. Hammerman, Roman Thomas, and Matthew Meyerson
5 Serum Proteomic Biomarkers, 90
Mohamed Hassanein and David P. Carbone
6 Molecular Biology of Lung Preneoplasia, 110
Humam Kadara and Ignacio I. Wistuba
7 Detection and Treatment of Preneoplastic Lesions, 129
Rachel Jen and Stephen Lam
8 Pathology of Adenocarcinoma, 144
William D. Travis
9 Management of Multifocal Bronchioloalveolar Carcinoma (BAC), 158
Howard West
10 Radiology and Lung Cancer Screening, 176
Patricia de Groot and Reginald F. Munden
11 Imaging Lung Cancer, 191
Sonia L. Betancourt Cuellar, Edith M. Marom, and Jeremy J. Erasmus
12 Staging of the Mediastinum, 202
Mauricio Pipkin and Shaf Keshavjee
13 Management of the Solitary Pulmonary Nodule, 214
Min P. Kim
14 Minimally Invasive Resections for Lung Cancer, 224
Shanda H. Blackmon
15 Extended Resections for Lung Cancer, 236
Matthew A. Steliga and David C. Rice
16 Bronchoscopic Interventions for Lung Cancer, 253
Donald R. Lazarus and George A. Eapen
17 Primary Tracheal Tumors, 267
Francesco Sammartino and Paolo Macchiarini
18 Adjuvant Chemotherapy Following Surgery for Lung Cancer, 278
Kathryn A. Gold
19 Neoadjuvant Chemotherapy for Resectable Non-Small Cell Lung Cancer, 290
Christopher G. Azzoli and Katherine M.W. Pisters
20 Image-Guided Radiation Therapy, 309
Kenneth E. Rosenzweig and Sonal Sura
21 Stereotactic Ablative Radiotherapy for Lung Cancer, 320
Puneeth Iyengar and Robert D. Timmerman
22 Proton Therapy, 338
Joe Y. Chang and James D. Cox
23 Combinations of Radiation Therapy and Chemotherapy for Non-small Cell and Small-Cell Lung Carcinoma, 353
Daniel Gomez, Zhongxing Liao, Pierre Saintigny, and Ritsuko U. Komaki
24 Individualized Radiotherapy by Dose Escalation and Altered Fractionation in Non-small Cell Lung Cancer, 379
Heath D. Skinner, Ritsuko U. Komaki, Joe Y. Chang, and James D. Cox
25 Molecular Target Treatment for Personalized Radiotherapy in Lung Cancer, 390
Steven H. Lin and Ritsuko U. Komaki
26 EGFR Tyrosine Kinase Inhibitors and Monoclonal Antibodies: Clinical Trial Review, 406
Kathryn F. Mileham, Edward S. Kim, and William N. William Jr
27 Mechanisms of Resistance to Epidermal Growth Factor Receptor (EGFR) in Non-small Cell Lung Cancer, 421
Erminia Massarelli
28 Predictive Tumor Biomarkers for EGFR Inhibitors, 435
Lucia Kim, Geoffrey Liu, and Ming-Sound Tsao
29 Immunologic Approaches to Lung Cancer Therapy, 454
Jay M. Lee, Steven M. Dubinett, and Sherven Sharma
30 Novel and Emerging Agents in NSCLC, 464
Anne S. Tsao and Jack A. Roth
31 Novel Clinical Trial Designs for Metastatic Lung Cancer, 479
Vassiliki A. Papadimitrakopoulou
32 Novel Statistical Models for NSCLC Clinical Trials, 488
J. Jack Lee and Caleb T. Chu
33 Tumor Microenvironment, Angiogenesis Biology, and Targeted Therapy, 505
John V. Heymach and Tina Cascone
34 Anti-angiogenic Agents in Metastatic NSCLC, 527
Millie Das and Heather Wakelee
35 Targeting ALK Rearrangements, 541
Justin F. Gainor and Alice T. Shaw
36 Non-small Cell Lung Cancers (NSCLC) with Mutations in BRAF, 557
Renata Ferrarotto and George R. Simon
37 Prognostic and Predictive Biomarker Signatures, 564
Johannes R. Kratz and David M. Jablons
38 Brain Metastasis from Lung Cancer, 572
Ritsuko U. Komaki and Amol J. Ghia
Index, 591
Color plate section between pages 146 and 147
Contributors
Christopher G. Azzoli, MD
Visiting Assistant Professor, Department of Medicine
Harvard Medical School
Massachusetts General Hospital
Boston, MA, USA
Sonia L. Betancourt Cuellar, MD
Department of Diagnostic Radiology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Shanda H. Blackmon, MD, MPH, FACS
Associate Professor, Houston Methodist Hospital, Weill Cornell Medical College of Cornell University, Houston, TX, USA
Clinical Assistant Professor, The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Lauren Averett Byers, MD, MS
Assistant Professor, Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
David P. Carbone, MD, PhD
Thoracic Oncology Center
James Comprehensive Cancer Center
Ohio State University Medical Center
Columbus, OH, USA
Tina Cascone, MD, PhD
Resident Physician
Department of Medicine, Division of Medical Education
Barnes-Jewish Hospital/Washington University School of Medicine in St. Louis
St. Louis, MO, USA
Joe Y. Chang, MD, MS, PhD
Professor
Clinical Section Chief, Department of Radiation Oncology
Director of Stereotactic Radiotherapy Program
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Caleb T. Chu, MD, MPH
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
James D. Cox, MD
Professor, Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Millie Das, MD
Clinical Assistant Professor, Division of Oncology
Stanford University/Stanford Cancer Institute
Stanford, CA, USA
Staff Oncologist
VA Palo Alto Heath Care System
Palo Alto, CA, USA
Patricia M. de Groot, MD
Assistant Professor, Department of Diagnostic Radiology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Steven M. Dubinett, MD
Chief of Pulmonary and Critical Care Medicine
Professor of Medicine and Pathology
Director of UCLA Lung Cancer Research Program
Division of Pulmonary and Critical Care Medicine
University of California at Los Angeles
Los Angeles, CA, USA
George A. Eapen, MD
Associate Professor, Department of Pulmonary Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Jeremy J. Erasmus, MD
Professor, Department of Diagnostic Radiology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Renata Ferrarotto, MD
Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Justin Gainor, MD
Clinical Fellow, Hematology/Oncology
Dana Farber Cancer Institute/Massachusetts General Hospital
Boston, Massachusetts, USA
Amol J. Ghia, MD
Assistant Professor, Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Kathryn A. Gold, MD
Assistant Professor, Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Daniel Gomez, MD
Assistant Professor, Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Peter Hammerman, MD, PhD
Assistant Professor of Medicine, Harvard Medical School, Boston, MA, USA
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Broad Institute of Harvard and MIT, Cambridge, MA, USA
Mohamed Hassanein, PhD
Research Assistant Professor of Medicine
Division of Allergy, Pulmonary and Critical Care Medicine
Vanderbilt University Medical Center
Nashville, TN, USA
John V. Heymach, MD, PhD
Chair, Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Waun Ki Hong, MD, DMSc (Hon)
American Cancer Society Professor
Samsung Distinguished University Chair in Cancer Medicine
Professor and Head, Division of Cancer Medicine
Professor, Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Karen Suchanek Hudmon, DrPH, MS, RPh
Associate Head for Operations, Department of Pharmacy Practice
Professor of Pharmacy
Purdue University
Indianapolis, IN, USA
Marcin Imielinski, MD, PhD
Broad Institute of Harvard and MIT, Cambridge, MA, USA
Department of Pathology, Massachusetts General Hospital
Boston, MA, USA
Puneeth Iyengar, MD, PhD
Assistant Professor, Department of Radiation Oncology
University of Texas Southwestern, Medical Center
Dallas, TX, USA
David Mark Jablons, MD
Professor and Chief Thoracic Surgery, UCSF Department of Surgery
Nan T. McEvoy Distinguished Professor of Thoracic Surgical Oncology
Ada Distinguished Professor of Thoracic Oncology
Program Leader Thoracic Oncology
UCSF Helen Diller Family Comprehensive Cancer Center
University of California
San Francisco, CA, USA
Rachel Jen, MD, FRCPC
Respiratory Division
Department of Medicine
University of British Columbia
Vancouver, British Columbia, Canada
Humam Kadara, PhD
Assistant Professor, Department of Translational Molecular Pathology
Division of Pathology and Laboratory Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Shaf Keshavjee, MD, MSc, FRCSC, FACS
Surgeon in Chief, UHN
James Wallace McCutcheon Chair in Surgery
Professor, Division of Thoracic Surgery & Institute of Biomaterials and Biomedical Engineering
University of Toronto
Toronto, ON, Canada
Edward S. Kim, MD
Chair, Solid Tumor Oncology and Investigational Therapeutics
Donald S. Kim Distinguished Chair for Cancer Research
Levine Cancer Institute
Carolinas HealthCare System
Charlotte, NC, USA
Lucia Kim, MD, PhD
Associate Professor, Department of Pathology
Inha University School of Medicine
Incheon, South Korea
Min P. Kim, MD
Assistant Professor
Weill Cornell Medical College
Department of Surgery
Division of Thoracic Surgery
Houston Methodist Hospital
Houston, TX, USA
Ritsuko U. Komaki, MD, FACR, FASTRO
Professor, Department of Radiation Oncology
Gloria Lupton Tennison Distinguished Endowed Professor in Lung Cancer Research
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Johannes R. Kratz, MD
Resident, Department of Surgery
Massachusetts General Hospital
Boston, MA, USA
Stephen Lam, MD, FRCPC
Professor of Medicine
University of British Columbia
Chair, Lung Tumour Group
BC Cancer Agency
Vancouver, BC, Canada
Donald R. Lazarus, MD
Interventional Pulmonology Fellow
Department of Pulmonary Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
J. Jack Lee, PhD, MS
Professor, Department of Biostatistics
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Jay M. Lee, MD
Chief, Division of Thoracic Surgery
Associate Professor of Surgery
UCLA Lung Cancer Research Program
Jonsson Comprehensive Cancer Center
David Geffen School of Medicine at UCLA
Los Angeles, CA, USA
Zhongxing Liao, MD
Professor and Clinical Director, Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Jie Lin, PhD
Department of Epidemiology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Steven H. Lin, MD, PhD
Assistant Professor, Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX, USA
Geoffrey Liu, MD, FRCPC
Associate Professor
Princess Margaret Hospital/Ontario Cancer Institute;
Department of Medicine, Medical Biophysics, and Epidemiology
University of Toronto
Toronto, ON, Canada
Paolo Macchiarini, MD, PhD
Professor of Regenerative Surgery, Director of Advanced Center of Translational Regenerative Medicine, Director of European Airway Institute and Senior Consultant of...
