Lung Cancer

Contributors, viii Preface, xiii 1 Smoking Prevention and Cessation, 1 Alexander V. Prokhorov and Karen Suchanek Hudmon 2 Lung Cancer Susceptibility and Risk Assessment Models, 25 Xifeng Wu, Xia Pu, and Jie Lin 3 Molecular Profiling, 48 Lauren Averett Byers 4 Somatic Genome Alterations in Human Lung Cancers, 67 Marcin Imielinski, Peter S. Hammerman, Roman Thomas, and Matthew Meyerson 5 Serum Proteomic Biomarkers, 90 Mohamed Hassanein and David P. Carbone 6 Molecular Biology of Lung Preneoplasia, 110 Humam Kadara and Ignacio I. Wistuba 7 Detection and Treatment of Preneoplastic Lesions, 129 Rachel Jen and Stephen Lam 8 Pathology of Adenocarcinoma, 144 William D. Travis 9 Management of Multifocal Bronchioloalveolar Carcinoma (BAC), 158 Howard West 10 Radiology and Lung Cancer Screening, 176 Patricia de Groot and Reginald F. Munden 11 Imaging Lung Cancer, 191 Sonia L. Betancourt Cuellar, Edith M. Marom, and Jeremy J. Erasmus 12 Staging of the Mediastinum, 202 Mauricio Pipkin and Shaf Keshavjee 13 Management of the Solitary Pulmonary Nodule, 214 Min P. Kim 14 Minimally Invasive Resections for Lung Cancer, 224 Shanda H. Blackmon 15 Extended Resections for Lung Cancer, 236 Matthew A. Steliga and David C. Rice 16 Bronchoscopic Interventions for Lung Cancer, 253 Donald R. Lazarus and George A. Eapen 17 Primary Tracheal Tumors, 267 Francesco Sammartino and Paolo Macchiarini 18 Adjuvant Chemotherapy Following Surgery for Lung Cancer, 278 Kathryn A. Gold 19 Neoadjuvant Chemotherapy for Resectable Non-Small Cell Lung Cancer, 290 Christopher G. Azzoli and Katherine M.W. Pisters 20 Image-Guided Radiation Therapy, 309 Kenneth E. Rosenzweig and Sonal Sura 21 Stereotactic Ablative Radiotherapy for Lung Cancer, 320 Puneeth Iyengar and Robert D. Timmerman 22 Proton Therapy, 338 Joe Y. Chang and James D. Cox 23 Combinations of Radiation Therapy and Chemotherapy for Non-small Cell and Small-Cell Lung Carcinoma, 353 Daniel Gomez, Zhongxing Liao, Pierre Saintigny, and Ritsuko U. Komaki 24 Individualized Radiotherapy by Dose Escalation and Altered Fractionation in Non-small Cell Lung Cancer, 379 Heath D. Skinner, Ritsuko U. Komaki, Joe Y. Chang, and James D. Cox 25 Molecular Target Treatment for Personalized Radiotherapy in Lung Cancer, 390 Steven H. Lin and Ritsuko U. Komaki 26 EGFR Tyrosine Kinase Inhibitors and Monoclonal Antibodies: Clinical Trial Review, 406 Kathryn F. Mileham, Edward S. Kim, and William N. William Jr 27 Mechanisms of Resistance to Epidermal Growth Factor Receptor (EGFR) in Non-small Cell Lung Cancer, 421 Erminia Massarelli 28 Predictive Tumor Biomarkers for EGFR Inhibitors, 435 Lucia Kim, Geoffrey Liu, and Ming-Sound Tsao 29 Immunologic Approaches to Lung Cancer Therapy, 454 Jay M. Lee, Steven M. Dubinett, and Sherven Sharma 30 Novel and Emerging Agents in NSCLC, 464 Anne S. Tsao and Jack A. Roth 31 Novel Clinical Trial Designs for Metastatic Lung Cancer, 479 Vassiliki A. Papadimitrakopoulou 32 Novel Statistical Models for NSCLC Clinical Trials, 488 J. Jack Lee and Caleb T. Chu 33 Tumor Microenvironment, Angiogenesis Biology, and Targeted Therapy, 505 John V. Heymach and Tina Cascone 34 Anti-angiogenic Agents in Metastatic NSCLC, 527 Millie Das and Heather Wakelee 35 Targeting ALK Rearrangements, 541 Justin F. Gainor and Alice T. Shaw 36 Non-small Cell Lung Cancers (NSCLC) with Mutations in BRAF, 557 Renata Ferrarotto and George R. Simon 37 Prognostic and Predictive Biomarker Signatures, 564 Johannes R. Kratz and David M. Jablons 38 Brain Metastasis from Lung Cancer, 572 Ritsuko U. Komaki and Amol J. Ghia Index, 591 Color plate section between pages 146 and 147