Pharmaceutical Bioassays

The definitive compendium of bioassay procedures andapplications A virtual encyclopedia of key bioassay protocols, thisup-to-date, essential resource reviews the methods and applicationsof bioassays that quantify drug activity and evaluate the validityof pharmacological models. Demonstrating the specific ways in which various pharmaceuticalbioassays interpret the activity of drug molecules, the book coversthe evaluation and screening of drug compounds in a wide spectrumof therapeutic categories. Throughout, the authors use various models to link experimentalobservations with findings that clarify the effect of drugcompounds on cellular biology and measure the pharmacologicalactivity of chemical substances. This provides an importanttechnological platform for successful drug research and clinicaltherapy, making Pharmaceutical Bioassays an ideal sourcebookfor pharmacologists, pharmaceutical and medical researchers,analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays isvital to understanding how bioactive agents and new drugs aredefined, discovered, and developed, so too is this indispensablereference, which: * Offers a complete reference on pharmaceutical bioassays andtheir specific applications in the assessment of therapies forcancer, Alzheimer's, diabetes, epilepsy, inflammation,antimalarials, pharmacogenomics, and other major therapeuticareas * Covers bioassays that measure toxicity, including those forchemical toxicity and hepatoxicity--a particularly significantconsideration in the development of safe and tolerablemedications * Highlights clinically relevant methods, ideas, and techniques tosupport any pharmaceutical researcher * Suggests guidelines and systems to enhance communication betweenpharmacologists, chemists, and biologists * Provides an informative analysis of pharmaceutical bioassaytechnologies and lab applications