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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
- Multi-contributed book and chapters are written by contributors who are experts in their field
- Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be
- Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications
- Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research
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ISBN-13
978-0-12-398303-9 (9780123983039)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
SECTION 1
1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications 2 Translating Pharmacogenomic Research to Therapeutic Potentials3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)
Section 2
4a Pharmacogenomics in Cancer Therapeutics4b A Look to the Future: Cancer epigenetics5a Pharmacogenomics in Cardiovascular Diseases 5b A Look to the Future: Cardiovascular Pharmaco-epigenetics6a Pharmacogenomics in Psychiatry Disorders6b A Look to the Future: Epigenetics in psychiatric disorders and treatment7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas
SECTION 3
8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development 9a Incorporating Pharmacogenomics in Drug DevelopmentPart 1: Rational study designs for pharmacogenetic research and therapy - A perspective from academia9b Incorporating Pharmacogenomics in Drug Development Part 2: A perspective from industry 10 Ethnobridging and Pharmacogenomics
SECTION 4
11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine12 The Economics of Pharmacogenomics
SECTION 5
13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough