Chromosomal Instability and Aging
Basic Science and Clinical Implications
Published on 29. January 2003
600 pages
978-1-135-54664-9 (ISBN)
Description
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, includ
More details
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
File size
28,02 MB
ISBN-13
978-1-135-54664-9 (9781135546649)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Book
06/2014
Marcel Dekker Inc
€147.08
Shipment within 15-20 days
Fuki Hisama | Sherman M. Weissman | George M. Martin
Chromosomal Instability and Aging
Basic Science and Clinical Implications
Book
01/2003
1st Edition
CRC Press
€217.01
Article not available at the moment
Persons
Fuki Hisama, Sherman M. Weissman, George M. Martin
Content
Introduction to the pathobiology of ageing; overview of chromosomal instability and ageing mechanisms. Replicative senescence, telomere regulation and chromosomal instability: cell senescence; telomere shortening and replicative ageing; telomere regulation in eukaryotic cells. Human premature ageing and chromosomal instability syndromes: Werner syndrome; Bloom syndrome - genetic, cellular and molecular features as compared to Werner syndrome; molecular biology of Rothmund-Thomson syndrome; molecular biology of Rothmund-Thomson syndrome. Ageing in model organisms: genomic instability and yeast ageing; the genetics of ageing in the nematode Caenorhabditis elegans; ageing, somatic maintenance, and genome stability Drosophilia melanogaster.
