Chromosomal Instability and Aging
Basic Science and Clinical Implications
1st Edition
Will be published approx. on 29. January 2003
Book
Hardback
608 pages
978-0-8247-0856-6 (ISBN)
Description
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
More details
Language
English
Place of publication
Bosa Roca
United States
Publishing group
Taylor & Francis Inc
Target group
Professional and scholarly
Professional and Professional Practice & Development
Dimensions
Height: 229 mm
Width: 152 mm
Weight
907 gr
ISBN-13
978-0-8247-0856-6 (9780824708566)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Fuki Hisama | Sherman M. Weissman | George M. Martin
Chromosomal Instability and Aging
Basic Science and Clinical Implications
E-Book
01/2003
CRC Press
€198.99
Available for download
Fuki M. Hisama | Sherman M. Weissman | George M. Martin
Chromosomal Instability and Aging
Basic Science and Clinical Implications
E-Book
01/2003
1st Edition
CRC Press
from
€150.00
Available for download
Persons
Fuki Hisama, Sherman M. Weissman, George M. Martin
Content
Introduction to the pathobiology of ageing; overview of chromosomal instability and ageing mechanisms. Replicative senescence, telomere regulation and chromosomal instability: cell senescence; telomere shortening and replicative ageing; telomere regulation in eukaryotic cells. Human premature ageing and chromosomal instability syndromes: Werner syndrome; Bloom syndrome - genetic, cellular and molecular features as compared to Werner syndrome; molecular biology of Rothmund-Thomson syndrome; molecular biology of Rothmund-Thomson syndrome. Ageing in model organisms: genomic instability and yeast ageing; the genetics of ageing in the nematode Caenorhabditis elegans; ageing, somatic maintenance, and genome stability Drosophilia melanogaster.