Computers and Computations in the Neurosciences
Published on 22. October 2013
602 pages
978-1-4832-5951-2 (ISBN)
Description
Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.
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10/1992
Academic Press
€100.28
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Content
Contributors to Volume 10PrefaceVolumes in SeriesSection I Data Collection 1. Neurophysiological Data Acquisition Based on Personal Microcomputer System 2. Personal Computer-Based Motion Control: A Tutorial and Application Using Simple Motor Controller to Drive Light Microscope Stage 3. Single-Unit Isolation from Multiunit Nerves by Dedicated Recording and Computation Methods 4. Computers in Study of Simultaneously Recorded Spike Trains: Organization of Neuronal Assemblies 5. Computer Methods in Nuclei Cartography 6. Quantitative Computerized Immunocytochemistry: Tissue Preparation and Image Analysis Techniques 7. Confocol Fluorescence Microscopy in Three-Dimensional Analysis of Axon Terminal Distribution, Neuronal Connectivity, and Colocalization of Messenger Molecules in Nervous Tissue: Computerized Analysis 8. Computer-Assisted Quantitative Receptor Autoradiography 9. Measuring Spatial Water Maze Learning 10. Measuring Discrimination LearningSection II Data Analysis 11. Computer Program for Kinetic Modeling of Gene Expression in Neurons 12. Computerized Optimization of Experimental Design for Estimating Binding Affinity and Binding Capacity in Ligand Binding Studies 13. Computerized Analysis of Opioid Receptor Heterogeneity by Ligand Binding in Guinea Pig Brain 14. Identification of Spikes by Computer 15. Computer Method for Identifying Bursts in Trains of Spikes 16. Computer Algorithms for Deconvolution-Based Assessment of In Vivo Neuroendocrine Secretory Events 17. Graded Action Potentials in Small Hippocampal Neurons: A Computational Approach 18. Quantification of Fast Axonal Transport by Video Microscopy 19. Use of Computers for Quantitative, Three-Dimensional Analysis of Dendritic Trees 20. Interactive Computer-Assisted Coding, Three-Dimensional Reconstruction, and Quantitative Analysis of Neuronal Perikarya, Processes, Spines, and Varicosities 21. Computerized Three-Dimensional Analysis of Shape of Synaptic Active Zones in Rat Spinal Cord 22. Statistical and Computational Methods for Quantal Analysis of Synaptic Transmission 23. Topography of Primary Muscle Afferent Neurons in Rat Dorsal Root Ganglia: A Three-Dimensional Computer-Aided Analysis 24. Computerized Morphometric Analysis of Neurons in Culture 25. Computerized Analysis of Polarized Neurite Growth 26. Computer-Assisted Methods for Analyzing Images of Olfactory BulbSection III Data Modeling and Simulations 27. Numerical Simulation of Cytosolic Calcium Oscillations Based on Inositol 1,4,5-Trisphosphate-Sensitive Calcium Channels 28. Models of Ion Channel Gating 29. Graphical Interactive Computer Simulation of Membrane Potential Measurements 30. Computer-Assisted Three-Dimensional Reconstruction and Dissection 31. Computer Simulations of Individual Neurons 32. Factors Influencing Neuronal Density on Sections: Quantitative Data Obtained by Computer Simulation 33. Physical Modeling of Neural NetworksIndex
