Prostate Cancer
Biology, Genetics, and the New Therapeutics
1st Edition
Published on 15. December 2000
XVIII, 531 pages
978-1-59259-009-4 (ISBN)
Description
This book embraces the wide field of prostate cancer genetics, biology, and therapy. It seems most appropriate to dedicate it to Donald S. Coffey, PhD, whose research vision is an inspiration to his colleagues and friends. Unraveling the secrets of prostate cancer is an intricate and sometimes frustrating process involving many researchers and many institutions. No one has seen through to the end of this road, and the list of researchers who have contributed to our understanding of the disease processes of prostate cancer is already a long one. But Donald Coffey stands out in his personal qualities as surely as in his roles as teacher and researcher. In the dedicatory article that begins this volume, Dr. Ward has spoken for all of us about Don Coffey's unique determination to build the road to defeat prostate cancer. This book is divided into three sections: Cancer Genetics, Cancer Biology, and Cancer Therapeutics. These sections, like the skill and knowledge of the contributors, overlap in many dimensions. The divisions between sections are somewhat arbitrary and have been made expressly for the convenience of the reader. The reader will find chapters in each section that illuminate aspects ofthe genetics, biology, and therapy of prostate cancer. Nothing better illustrates the breadth of the research being conducted today by these distinguished groups, who truly understand and appreciate the power of multi disciplinary and translational approaches to deciphering the intricacy of the object of this research.
Reviews / Votes
"...the editors have done a remarkable job in selecting the topics and compiling the various articles into a comprehensive and easily accessible volume. The chapters are concise and informative, covering highly innovative studies being conducted in the field of recent years...the complexity of prostate cancer biology is well represented in the book, and the resourceful information can benefit not only those who are interested in prostate biology, but also those researchers employing molecular and cellular approaches to solve other important biological questions." - Quarterly Review of Biology"...a welcome addition to the literature...The main strength of this book is that experts from several disciplines have contributed their thoughts on recent advances in prostate cancer...I strongly recommend this book to researchers who study prostate cancer, whether at the bench or at the bedside, and to clinicians who treat patients with prostate cancer... the book covers our current knowledge of prostate cancer and its treatment and helps define the foundation for future directions." - New England Journal of Medicine
"Well researched and extensively referenced, the book provides a valuable source of information on the current state of understanding of the molecular biology of prostate cancer, and the treatment modalities in routine clinical practice." - ACP News
"Each chapter is presented in a way that provides all available knowledge on the subject and the book structure allows readers to use a single section or chapter according to their interests. All these characteristics make the book a valuable tool to general oncologists or urologists interested in updating their basic knowledge of prostate cancer." -Annals of Oncology
More details
Series
Language
English
Place of publication
Totowa
United States
Publishing group
Humana Press
Target group
Professional and scholarly
Product notice
Reflowable
Illustrations
XVIII, 531 p. 59 illus., 1 illus. in color.
File size
81,54 MB
ISBN-13
978-1-59259-009-4 (9781592590094)
DOI
10.1007/978-1-59259-009-4
Schweitzer Classification
Other editions
New editions
Leland W. K. Chung | William B. Isaacs | Jonathan W. Simons
Prostate Cancer
Biology, Genetics, and the New Therapeutics
E-Book
11/2007
2nd Edition
Humana
€149.79
Available for download
Additional editions
Book
01/2001
Humana Press Inc.
€85.59
Article exhausted; check for reprint
Content
I. Introduction.- 1 Building the Road to Defeat Prostate Cancer: A Dedication to Donald S. Coffey.- II. Cancer Genetics.- 2 Hereditary Prostate Cancer.- 3 AR Gene Alterations in Prostate Cancer Progression.- 4 Lethal Metastatic Human Prostate Cancer: Autopsy Studies and Characteristics of Metastases.- 5 Tumor Suppressor Genes in Prostate Cancer.- 6 Androgen Receptor Polymorphisms and Prostate Cancer Risk.- 7 The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease.- 8 Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques.- 9 Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN).- 10 Xenograft Models and the Molecular Biology of Human Prostate Cancer.- 11 Comprehensive Analyses of Prostate Gene Expression.- III. Cancer Biology.- 12 The Role of Nuclear Matrix and Cytoskeleton in Cancer.- 13 The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis.- 14 Ligand Dependent and Independent Activation of the Androgen Receptor.- 15 Tyrosine Kinases and Cellular Signaling in Prostate Cancer.- 16 Molecular Pathways Underlying Prostate Cancer Progression: The Role of Caveolin-1.- 17 Angiogenesis and Prostate Cancer.- 18 Prostate Specific Membrane Antigen.- 19 Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer.- 20 Stromal-Epithelial Interaction: From Bench to Bedside.- IV. Cancer Therapeutics.- 21 Chemoprevention of Prostate Cancer.- 22 Anatomic Radical Retropubic Prostatectomy for Prostate Cancer.- 23 Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical, and Biologic Considerations.- 24 Prostate Cancer Chemotherapy: Closing Out a Century and Opening a New One.- 25 The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer.- 26 Development of Dendritic Cell-Based Prostate Cancer Vaccine.- 27 Antiprogression Agents for Prostate Cancer.- 28 Human Gene Therapy for Urological Oncology.- 29 Chemoprevention Trials for Prostate Cancer.
