Principles of Bone Biology

Part I Basic PrinciplesA. Cell Biology1: Structure, Modeling and Remodeling of Bone / The Size and Shape of Bone as a Site of Metabolic Bone Activity2: Biomechanics of Bone3: Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation4: Mesenchymal Stem Cells & Osteoblast Lineage5: Transcriptional Control of Osteoblast Differentiation and Function6: Wnt Signaling and Bone7: Sclerostin and Bone8: The Osteocyte9: Cells of Bone: Osteoplast Generation10: Osteoclast Function: Biology and Mechanisms11: RANK Signaling12: Regulating Bone Resorption13: Apoptosis in Bone Cells14: Skeletal Gene Expression in Nuclear MicroenvironmentsB. Biochemistry15: Type I Collagen: Structure, Synthesis, and Regulation16: Collagen Crosslinking & Metabolism17: Bone Matrix Proteoglycans & Glycoproteins18: Osteopontin19: Bone Proteinases20: Integrins and Other Cell Surface Attachment Molecules of Bone Cells21: Intercellular Junctions and Cell-Cell Communication in the Skeletal SystemC. Bone Remodeling and Mineral Homeostasis22: Histomorphometric Analysis of Bone Remodeling23: Phosphorus Homeostasis & Related Disorders24: Magnesium Homeostasis25: Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & Stro26: Biology of the Extracellular Ca2+-Sensing Receptor D. The Hormones of Bone27: Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein28: Parathyroid Hormone - Molecular Biology29: Parathyroid Hormone-Receptor Interactions30: Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System31: The Vascular and Cardiovascular Actions of PTH32: PTH and PTHrP Actions on Kidney and Bone33: Physiological Actions of Parathyroid Hormone and PTH-Related Protein34: Vascular, Cardiovascular and Neurological Actions of Parathyroid-Related Protein35: Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses36: Vitamin D Gene Regulation37: Photobiology and Non-Calcemic Actions of Vitamin D38: Calcitonin Structure and Molecular Biology of the Calcitonin Receptor / Calcitonin Gene Family and Receptors: Structure, Molecular Biology, and Effects39: Amylin and Calcitonin Gene-Related PeptideE. Other Systemic Hormones That Influence Bone Metabolism40: Estrogens & Progestins41: The Pharmacology of Selective Estrogen Receptor Modulators42: Mechanisms of Estrogen Action in Bone43: Thyroid Hormone & Bone44: Clinical and Basic Aspects of Glucocorticoid Action in Bone45: Effects of Diabetetes & Insulin on Bone Physiology46: Androgens:Receptor Expression and Steroid Action in Bone47: Kinins & Neuro-Osteogenic Factors48: Regulation of Bone Remodeling by Central and Peripheral Nervous SignalsPatricia DucyF.