PART I: BASIC PRINCIPLESCell BiologyThe Structure & Development of the SkeletonBiomechanics of BoneEmbryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone FormationMesenchymal Stem Cells & Osteoblast LineageTranscriptional Control of Osteoblast Differentiation and FunctionThe OsteocyteCells of Bone: Osteoclast GenerationOsteoclast FunctionIntegrin and Calcitonin Receptor Signaling in the Regulation of the Cytoskeleton and Function of OsteoclastsApoptosis in Bone CellsInvolvement of Nuclear Architecture in Regulating Gene Expression in Bone CellsBiochemistryType I Collagen: Structure, Synthesis, and RegulationCollagen Crosslinking & MetabolismBone Matrix Proteoglycans & GlycoproteinsOsteopontinBone ProteinasesCell Surface Attachment MoleculesIntercellular Junctions and Cell-Cell Communication in BoneBone Remodeling and Mineral HomeostasisHistomorphometric Analysis of Bone RemodelingPhosphorus Homeostasis & Related DisordersMagnesium HomeostasisMetals in Bone: Aluminum, Boron, Cadmium, Chromium, Lead, Silicon, & StrontiumThe Biology of the Extracellular Ca2+-Sensing Receptor (CaR)The Hormones of BoneReceptors for Parathyroid Hormone and Parathyroid Hormone-Related PeptideParathyroid Hormone - Molecular BiologyParathyroid Hormone-Receptor InteractionsActions of Parathyroid HormoneRenal and Skeletal Actions of PTH and PTHrPPhysiological Actions of PTH and PTHRP: Epidermal, Mammary, Reproductive and Pancreatic IssuesVascular, Cardiovascular and Neurological Actions of PTHrPNuclear Receptor Structure (VDR) and Ligand Specificities for Genomic and Rapid Biological ResponsesVitamin D Gene RegulationPhotobiology and Non-Calcemic Actions of Vitamin DThe Structure and Molecular Biology of the Calcitonin ReceptorPhysiology & Pathophysiology of CalcitoninAmylin & CGRPOther Systemic Hormones That Influence Bone MetabolismEstrogens & ProgestinsSelective Estrogen Receptor Modulators (SERMs)Mechanisms of Estrogen Action in BoneThyroid Hormone & BoneClinical and Basic Aspects of Glucocorticoid Action in BoneEffects of Diabetes & Insulin on Bone PhysiologyAndrogens: Receptor Expression and Steroid Action in BoneKinins & Neuro-Osteogenic FactorsLocal RegulatorsThe Role of Insulin-like Growth Factors & Binding Proteins in Bone Cell BiologyPlatelet-Derived Growth Factor & the SkeletonFibroblast Growth Factor and Fibroblast Growth Factor Receptor Families in BoneVascular Endothelial Growth FactorsTransforming Growth Factor (beta)Bone Morphogenetic ProteinsBone Morphogenetic Protein Receptors & ActionsColony-Stimulating FactorsLocal Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, IL-8, IL-10, IL-4, the LIF/IL-6 Family, and Additional CytokinesProstaglandins & Bone MetabolismNitric Oxide and other Vasoactive AgentsPART II: MOLECULAR MECHANISMS OF METABOLIC BONE DISEASESMolecular Basis of PTH OverexpressionFamilial Benign Hypocalciuric Hypercalcemia and Neonatal Primary HyperparathyroidismMultiple Endocrine Neoplasia Type IThe Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2Systemic Factors in Skeletal Manifestations of MalignancyLocal Factors in Skeletal MalignancyMolecular Basis of PTH UnderexpressionJansen's Metaphyseal Chondrodysplasia & Blomstrand's Lethal Chondrodysplasia: Two Genetic Disorders Caused by PTH/PTHrP Receptor MutationsSignal Transduction via G Proteins; PseudohypoparathyroidismOther Skeletal Diseases Resulting from G Protein Defects - Fibrous Dysplasia & McCune-Albright SyndromeOsteogenesis ImperfectaHereditary Deficiencies in Vitamin D Action.