Late-Stage Functionalization and Diversification in Organic Synthesis
Methods and Applications
1st Edition
Published on 13. March 2026
336 pages
978-3-527-84844-7 (ISBN)
Description
Provides a much-needed overview of the most important methods for the late-stage transformation of complex molecules, such as C-H functionalization, C-X bond activation, cross-coupling reactions, fluorination, etc.
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Tatiana Besset
Late-Stage Functionalization and Diversification in Organic Synthesis
Methods and Applications
Book
04/2026
1st Edition
Wiley-VCH
€149.00
Available immediately
Persons
Tatiana Besset is a CNRS Research Director at Rouen Normandy University, (UMR6064 CARMeN Institute, INSA Rouen Normandy), France. Her research has been recognized by several awards and honors, including the CNRS Bronze Medal, the "SCF" Jean-Pierre Sauvage and Jean-Marie Lehn Prize, the Thieme Chemistry Journals Award, and the RSC Fluorine Prize. Elected as a Chemistry Europe Fellow in 2022, her research focuses on the development of new transition metal-catalyzed transformations, C-H bond functionalization, and innovative strategies in organofluorine chemistry.
Content
Foreword
Preface
PART I: LATE-STAGE FUNCTIONALIZATION STRATEGIES
1. Late-Stage Functionalization by Transition Metal Catalyzed C-H Functionalization
2. Light-Triggered Methods for Late-Stage Functionalization
3. Electrochemical Late-Stage Functionalization
4. Flow Chemistry Applied for Late-Stage Functionalization and other Functional Group-Tolerant Manipulation
5. Radioisotope Insertion through Late-Stage Functionalization
PART II: DIVERSITY-ORIENTED SYNTHESIS
6. Late-Stage Functionalization Strategies Using C-O Bond Activation
7. C-N Bond Activation under Redox-Neutral Conditions
8. Late-Stage Functionalization by C-S Bond Activation
PART III: MOLECULAR/STEREOCHEMICAL EDITING
9. Molecular Editing as an Efficient Tool to Access Functionalized Organic Molecules
Preface
PART I: LATE-STAGE FUNCTIONALIZATION STRATEGIES
1. Late-Stage Functionalization by Transition Metal Catalyzed C-H Functionalization
2. Light-Triggered Methods for Late-Stage Functionalization
3. Electrochemical Late-Stage Functionalization
4. Flow Chemistry Applied for Late-Stage Functionalization and other Functional Group-Tolerant Manipulation
5. Radioisotope Insertion through Late-Stage Functionalization
PART II: DIVERSITY-ORIENTED SYNTHESIS
6. Late-Stage Functionalization Strategies Using C-O Bond Activation
7. C-N Bond Activation under Redox-Neutral Conditions
8. Late-Stage Functionalization by C-S Bond Activation
PART III: MOLECULAR/STEREOCHEMICAL EDITING
9. Molecular Editing as an Efficient Tool to Access Functionalized Organic Molecules
