Organic Synthesis
4th Edition
Published on 31. December 2016
Book
Hardback
1106 pages
978-0-12-800720-4 (ISBN)
Description
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature.
In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry.
Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching.
In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry.
Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. A full Solutions Manual is also available online for qualified instructors, to support teaching.
More details
Edition
4th edition
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
College/higher education
Illustrations
Approx. 800 illustrations
Dimensions
Height: 276 mm
Width: 216 mm
Weight
3130 gr
ISBN-13
978-0-12-800720-4 (9780128007204)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Michael Smith
Organic Synthesis
Book
10/2024
5th Edition
Academic Press
€161.50
Shipment within 15-20 days
Additional editions
Previous edition
Michael Smith
Organic Synthesis
Book
07/2011
3rd Edition
Wavefunction, Incorporated
€133.92
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Person
Professor Michael B. Smith received an A.A. from Ferrum College in 1967 and a BS in chemistry from Virginia Polytechnic Institute in 1969. After working for 3 years at the Newport News Shipbuilding and Dry Dock Co. in New- port News VA as an analytical chemist, he entered graduate school at Purdue University. He received a PhD in Organic Chemistry in 1977. He spent 1 year as a faculty research associate at the Arizona State University with Professor G. Robert Pettit, working on the isolation of cytotoxic principles from plants and sponges. He spent a second year of postdoctoral work with Professor Sidney M. Hecht at the Massachusetts Insti- tute of Technology, working on the synthesis of bleomycin A2.?
Smith began his academic career at the University of Connecticut in 1979, where he is currently professor of chemistry.?In addition to this research, he is the author of the fifth, sixth, and seventh editions of March's Advanced Organic Chemistry. He is also the author of an undergraduate textbook in organic chemistry titled Organic Chemistry. An Acid-Base Approach, now in its second edition. He is the editor of the Compendium of Organic Synthetic Methods, Volumes 6-13. He is the author of Organic Chemistry: Two Semesters, in its second edition, which is an outline of undergraduate organic chemistry to be used as a study guide for the first organic course. He has authored a research monograph titled Synthesis of Non-alpha Amino Acids, in its second edition.
Smith began his academic career at the University of Connecticut in 1979, where he is currently professor of chemistry.?In addition to this research, he is the author of the fifth, sixth, and seventh editions of March's Advanced Organic Chemistry. He is also the author of an undergraduate textbook in organic chemistry titled Organic Chemistry. An Acid-Base Approach, now in its second edition. He is the editor of the Compendium of Organic Synthetic Methods, Volumes 6-13. He is the author of Organic Chemistry: Two Semesters, in its second edition, which is an outline of undergraduate organic chemistry to be used as a study guide for the first organic course. He has authored a research monograph titled Synthesis of Non-alpha Amino Acids, in its second edition.
Content
1. Retrosynthesis, Stereochemistry, and Conformations2. Acids, Bases and Functional Group Exchange Reactions3. Protecting Groups4. Synthetic Strategies5. Oxidation6. Reduction7. Hydroboration8. Stereocontrol and Ring Formation9. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds10. Cd Disconnect Products: S and P Carbanions11. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions12. Pericyclic Reactions: The Diels-Alder Reaction13. Pericyclic Reactions: [m+n]-Cycoadditions, Sigmatropic Rearrangements, Electrocyclic and Ene reactions14. Ca Disconnect Products: Electrophilic Carbon-Carbon Bond Forming Reactions15. Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds Via Radicals and Carbenes 16. Metal-Mediated Reactions17. Process Chemistry and Combinatorial Chemistry