Handbook of the Biology of Aging
8th Edition
Published on 14. October 2015
Book
Paperback/Softback
576 pages
978-0-12-411596-5 (ISBN)
Description
Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.
The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.
The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.
More details
Series
Edition
8th edition
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Clinicians, researchers, and students in gerontology, developmental psychology, psychiatry, biology, and other related health care professions tasked with caring for the aging population
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 233 mm
Width: 189 mm
Thickness: 30 mm
Weight
1182 gr
ISBN-13
978-0-12-411596-5 (9780124115965)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Nicolas Musi | Peter Hornsby
Handbook of the Biology of Aging
Book
01/2021
9th Edition
Academic Press
€122.50
Shipment within 15-20 days
Additional editions
Nicolas Musi | Peter Hornsby
Handbook of the Biology of Aging
E-Book
08/2015
8th Edition
Academic Press
€71.95
Available for download
Previous edition
Edward J. Masoro | Steven N. Austad
Handbook of the Biology of Aging
Book
12/2010
7th Edition
Academic Press
€90.36
Article exhausted; check for reprint
Persons
Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging. Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.
Content
Foreword
Preface
Section I: Basic Mechanisms of Aging: Models and Systems
Chapter 1 - Longevity as a Complex Genetic Trait
George L. Sutphin and Ron Korstanje
Chapter 2 - The mTOR Pathway and Aging
Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy
Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals
William Giblin and David B. Lombard
Chapter 4 - The Hypoxic Response and Aging
Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein
Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging
Michael J. Waterson and Scott D. Pletcher
Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan
Kaitlyn N. Lewis and Rochelle Buffenstein
Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease
Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson
Chapter 8 - Systems Approaches to Understanding Aging
Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han
Chapter 9 - Integrative Genomics of Aging
Joao Pedro de Magalhaes and Robi Tacutu
Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging
Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison
Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species
Michael Van Meter, Vera Gorbunova, and Andrei Seluanov
Section II: The Pathobiology of Human Aging
Chapter 12 - Genetics of Human Aging
Miook Cho and Yousin Suh
Chapter 13 - The Aging Arterial Wall
Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta
Chapter 14 - Age-Related Alterations in Neural Plasticity
Shannon J. Moore and Geoffrey G. Murphy
Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention
Ludmila Mueller and Graham Pawelec
Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms
Ingrid A. Harten, Michelle Olive, and Thomas N. Wight
Chapter 17 - Cardiac Aging
Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch
Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity
Eileen M. Cr4immins and Morgan E. Levine
Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond
James F. Fries
Preface
Section I: Basic Mechanisms of Aging: Models and Systems
Chapter 1 - Longevity as a Complex Genetic Trait
George L. Sutphin and Ron Korstanje
Chapter 2 - The mTOR Pathway and Aging
Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy
Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals
William Giblin and David B. Lombard
Chapter 4 - The Hypoxic Response and Aging
Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein
Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging
Michael J. Waterson and Scott D. Pletcher
Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan
Kaitlyn N. Lewis and Rochelle Buffenstein
Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease
Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson
Chapter 8 - Systems Approaches to Understanding Aging
Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han
Chapter 9 - Integrative Genomics of Aging
Joao Pedro de Magalhaes and Robi Tacutu
Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging
Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison
Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species
Michael Van Meter, Vera Gorbunova, and Andrei Seluanov
Section II: The Pathobiology of Human Aging
Chapter 12 - Genetics of Human Aging
Miook Cho and Yousin Suh
Chapter 13 - The Aging Arterial Wall
Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta
Chapter 14 - Age-Related Alterations in Neural Plasticity
Shannon J. Moore and Geoffrey G. Murphy
Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention
Ludmila Mueller and Graham Pawelec
Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms
Ingrid A. Harten, Michelle Olive, and Thomas N. Wight
Chapter 17 - Cardiac Aging
Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch
Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity
Eileen M. Cr4immins and Morgan E. Levine
Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond
James F. Fries