Cell Culture Models of Biological Barriers
In vitro Test Systems for Drug Absorption and Delivery
1st Edition
Published on 8. August 2002
Book
Hardback
472 pages
978-0-415-27724-2 (ISBN)
Description
Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and enhanced absorption. Compared to in vivo trials on animals or humans, cell culture models are faster, more convenient and cost effective, ethically advantageous and, most importantly, they can be more easily standardized and validated.
This book provides a practical approach to contemporary cell culture-based in vitro techniques for drug transport studies at biological absorption barriers. It is an invaluable source of information for students attending graduate courses on this subject and pharmaceutical scientists working in industry or in academia.
This book provides a practical approach to contemporary cell culture-based in vitro techniques for drug transport studies at biological absorption barriers. It is an invaluable source of information for students attending graduate courses on this subject and pharmaceutical scientists working in industry or in academia.
More details
Language
English
Place of publication
London
United Kingdom
Publishing group
Taylor & Francis Ltd
Target group
Professional and scholarly
Academic and Professional Reference
Dimensions
Height: 260 mm
Width: 183 mm
Thickness: 30 mm
Weight
1075 gr
ISBN-13
978-0-415-27724-2 (9780415277242)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
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Additional editions
Claus-Michael Lehr
Cell Culture Models of Biological Barriers
In vitro Test Systems for Drug Absorption and Delivery
Book
10/2019
1st Edition
CRC Press
€128.70
Shipment within 15-20 days
Claus-Michael Lehr
Cell Culture Models of Biological Barriers
In vitro Test Systems for Drug Absorption and Delivery
E-Book
08/2002
1st Edition
CRC Press
€89.99
Available for download
Claus-Michael Lehr
Cell Culture Models of Biological Barriers
In vitro Test Systems for Drug Absorption and Delivery
E-Book
08/2002
1st Edition
CRC Press
€89.99
Available for download
Person
Claus-Michael Lehr
Content
General Aspects of Epithelial Cell and Tissue Culture. Basic Aspects of Cell Growth and Cell Cycle in Culture. Cell Culture Media: Selection and Standardization. Bioelectrical Characterization of Epithelial Cell (Mono)Layers and Tissues. Characterization of Transport Over Epithelial Barriers. Studying Cellular Binding and Uptake of Bioadhesive Lectins. High-throughput Epithelial Cell Culture Systems for Screening Drug Intestinal Permeability. Good Cell Culture Practice (GCCP). Regulatory Acceptance of in vitro Test Systems as an Alternative to Safety Testing in Animals. Regulatory Acceptance of in vitro Permeability Studies in the Context of the Biopharmaceutics Classification System. Models of Specific Epithelial and Endothelial Barriers Relevant to Drug Delivery. Caco-2 Cell Monolayers as a Model for Studies of Drug Transport Across Human Intestinal Epithelium. Transport Studies Using Intestinal Tissue ex vivo. Models of Alveolar Epithelium. Bronchial Epithelial Cell Cultures. In vitro Methodologies to Study Nasal Delivery Using Excised Mucosa. Cell Culture Models of the Corneal and Conjunctival Epithelium. Cell Cultures of the Retinal Pigment Epithelium to Model the Blood-retina Barrier for Retinal Drug and Gene Delivery. Human Skin and Skin Equivalents to Study Dermal Penetration and Permeation. In vitro Models of the Human Buccal Epithelium: the TR146 Cell Culture Model and the Porcine in vitro Model. Drug Transport Across the Blood-brain Barrier: A Molecular and Functional Perspective. BeWo Cells: An in vitro System Representing The Blood-placental Barrier. Emerging Tools for Studying Biological Barriers and Drug Transport. Predicting Drug Absorption by Computational Methods. Confocal and Two-photon Fluorescence Microscopy. On the Application of Scanning Force Microscopy in Cell Biology. Fluorescence Correlation Spectroscopy.