
Gene Interactions in Development
L. I. Korochkin(Author)
A. Grossman(Editor)
Springer (Publisher)
Published on 19. January 2012
Book
Paperback/Softback
XIV, 320 pages
978-3-642-81479-2 (ISBN)
Description
Since the Russian edition of this book was published in 1975 many new research works have appeared which have made necessary some additions for the English edition, to reflect progress in molecular developmental genetics. Recent important findings in this field have brought about essential corrections to the concept of genetic regulation of the process of cell differentiation. The discovery of the mosaic structure of a gene prompted the re evaluation of our considerations about the regulation of gene activity in eukaryotes, and the data about transcriptional events during ontogenesis are of great importance as well. Formerly it was generally accepted that a derepression of genes was responsible for cell differentiation in the process of develop ment. Recently three important conclusions have been derived (Davidson and Britten, 1979) which help to pose the problem in a new way: 1) Only a small part of single copy sequences of DNA is represented in nuclear RNA of a given type of cell or tissue: 10% to 20% in sea urchin embryos, 11 % in rat liver, 4% to 6% in Drosophila cell culture, etc. Since only about 10% of single copy sequences represent the structural genes (Davidson and Britten, 1973), transcription of almost the whole set of structural genes occurs.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1981
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
XIV, 320 p.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 19 mm
Weight
588 gr
ISBN-13
978-3-642-81479-2 (9783642814792)
DOI
10.1007/978-3-642-81477-8
Schweitzer Classification
Other editions
Additional editions

L. I. Korochkin | A. Grossman
Gene Interactions in Development
E-Book
12/2012
Springer
€96.29
Available for download

L. I. Korochkin | A. Grossman
Gene Interactions in Development
Book
02/1981
Springer
€139.09
Article exhausted; check different version
Persons
Content
1 Gene Interaction at the Cellular Level.- 1.1 Differential Activity of Genes as a Basis for Cell Dif-ferentiation.- 1.2 The Realization of Differential Gene Activity on the Post-Transcriptional, Translational, and Post-Translational Levels.- 1.3 The Phenomenon of Allelic Exclusion.- 1.4 Nuclear-Cytoplasmic Interactions. The Basis for the Regulation of Gene Activity.- 2 Gene Interaction at the Tissue Level.- 2.1 Functional-Genetic Mosaicism in Cell Regulation.- 2.2 Genetic Heterogeneity and the Establishment of Tissue Systems During Development.- 2.3 Genetic Regulation of Ontogenesis on the Organismal Level.- 2.4 The Organization of Systems Which Control Differential Gene Expression.- Conclusion.- References.