Oxford Textbook of Rheumatology

SECTION 1: CLINICAL PRESENTATION OF RHEUMATIC DISEASE; 1.1 Clinical presentations in different age groups; 1.1.1 The adult patient; 1.1.2 The child; 1.1.3 Adolescence and transition; 1.1.4 The geriatric age group; 1.1.5 Principles of examination; 1.1.6 Psychological aspects of rheumatic disease; 1.1.7 Growth and skeletal maturation; 1.2 Common clinical problems; 1.2.1.1 Spinal problems in adults; 1.2.1.2 Spinal problems in children; 1.2.2 Regional problems; 1.2.2.1 The upper limbs in adults; 1.2.2.2. The lower limbs in adults; 1.2.2.3 The arm and leg in children; 1.2.3 Extra-articlular features of rheumatic diseases; 1.3 Views from different perspectives; 1.3.1 Pregnancy and lactation; 1.3.1.1 Pregnancy; 1.3.1.1.2 Antirheumatic drugs in pregnancy & lactation; 1.3.2 The skin and rheumatic disease; 1.3.3 Neurological complications; 1.3.4 The cardiovascular system; 1.3.5 The respiratory system; 1.3.6 The gastrointestinal tract; 1.3.7 Liver, spleen and pancreas; 1.3.8 The endocrine system; 1.3.9 Oncology; 1.3.10 Haematology; 1.3.11 An anaesthetic perspective; 1.3.12 The eye; 1.3.13 The kidney; 1.3.14 Psychiatric issues in rheumatology; SECTION 2: OUTCOMES AND ISSUES IN DELIVERING RHEUMATOLOGICAL CARE; 2.1 Outcome assessment in rheumatology; 2.2 Rehabilitation of adults; 2.3 Rehabilitation of children; 2.4 Rheumatic disease and sexuality; 2.5 Health cost economics and rheumatology; SECTION 3: PATHOPHYSIOLOGY OF MUSCULOSKELETAL DISEASE; 3.1 Genomics and its relevance to rheumatology; 3.2 Molecular abnormalities of collagen and connective tissue; 3.3 Articular cartilage; 3.4 Bone in health and disease; 3.5 The physiology of the joint and its disturbance in inflammation; 3.6 Synovial pathology; 3.7 Skeletal muscle physiology and damage; 3.8 Biomechanics of articulations and derangements in disease; SECTION 4: THE PROCESS OF INFLAMMATION; 4.1 Cells, cytokines and chemokines; 4.2 Leukocyte trafficking in inflammation; 4.3 Specific immune responses; 4.4 Animal models of arthritis; 4.5 Modification of Inflammation; 4.5.1 Non-steroidal anti-inflammatory drugs - old and new; 4.5.2 The place of corticosteroids in the management of rheumatic disease; 4.5.3 Immunosuppressive and other drugs - monotherapy vs combination therapy; 4.5.4 The future targets; SECTION 5: INVESTIGATION OF THE RHEUMATIC DISEASES; 5.1 Acute phase response; 5.2 Biochemistry; 5.3 Microbiology and diagnostic serology; 5.4 Immunology laboratory tests; 5.5 Joint fluid; 5.6 Imaging; 5.6.1 Imaging in adults; 5.6.2. Imaging in children; 5.7 Histopathology; 5.8 Electrophysiology; SECTION 6: THE SCOPE OF RHEUMATIC DISEASE; 6.1 Epidemiology; 6.1.1 Epidemiology and the rheumatic diseases; 6.1.2 Epidemiology of rheumatic diseases in selected non-European populations; 6.2 Infections; 6.2.1 Pyogenic arthritis in adults; 6.2.2 Pyogenic arthritis in children; 6.2.3 Osteomyelitis and associated conditions; 6.2.4 Lyme disease; 6.2.5 Viral arthritis; 6.2.6 HIV infection; 6.2.7 Myobacterial diseases; 6.2.8 Brucellar arthritis; 6.2.9 Parasitic involvement; 6.2.10 Fungal arthritis; 6.2.11 Immunodeficiency; 6.2.12 Rheumatic fever; 6.3 Rheumatic arthritis; 6.3.1 Immunopathogenesis of rheumatoid arthritis; 6.3.2 Rheumatoid arthritis - the clinical picture; 6.3.3 Rheumatoid arthritis - management; 6.3.4 Polyarticular rheumatoid factor positive (seropositive) juvenile idiopathic arthritis; 6.4 Rheumatic arthritis; 6.4.1 Spondylarthropathy, undifferentiated spondylarthritis and overlap; 6.4.2 Spondylarthritis in childhood; 6.4.3 Ankylosing spondylitis; 6.4.4 Psoriatic arthritis; 6.4.5 Reactive arthritis and enteropathic arthropathy; 6.5 Arthropathies primarily occurring in childhood; 6.5.1 Pauciarticular-onset juvenile chronic arthritis; 6.5.2 Systemic-onset juvenile chronic arthritis; 6.5.3 Rheumatoid factor-negative polyarthritis in children; 6.6 Systemic lupus erythematosus; 6.6.1 Systemic lupus erythematosus in adults - clinical features and aetiopathogenesis; 6.6.2 SLE - management in adults; 6.6.3 Paediatric systemic lupus erythematosus; 6.6.4 The antiphospholid antibody syndrome; 6.7 Scleroderma and related disorders in adults and children; 6.8 Polymyositis and dermamyositis; 6.8.1 Polymyositis and dermamyositis in adults; 6.8.2 Polymyositis and dermamyositis in children; 6.9 Sjogren's syndrome; 6.10 Vasculitis; 6.10.1 Classification and epidemiology of vasculitis; 6.10.2 Clinical features of primary ANCA-associated vasculitis; 6.10.3 Treatment of primary ANCA-associated vasculitis; 6.10.4 Secondary vasculitis and vasculitis mimics; 6.10.5 Large vessel vasculitis/gian cell arteritis; 6.10.6 Polymyaligia rheumatica; 6.10.7 Other vasculitides including small vessel vasculitis; 6.10.8 Behcet's syndrome; 6.10.9 Vasculitis in children; 6.11 Overlap syndromes in adults and children; 6.12 Miscellaneous inflammatory conditions; 6.12.1 Amyloidosis; 6.12.2. Familial Mediterranean fever; 6.12.3 Periodic fevers; 6.12.4 Panniculitis; 6.12.5 Neurtophilic dermatoses; 6.12.6 Sarcoidosis; 6.12.7 Macrophage activation syndrome; 6.12.8 The chronic, infantile, neurological, cutaneous and articular syndrome; 6.12.9 Multicentric reticulohistiocytosis; 6.12.10 Hyperlipidaemias; 6.13 Soft Tissue Rheumatism; 6.13.1 Fibromyalgia and diffuse pain syndromes - adult onset; 6.13.2 Local pain syndromes - adult onset; 6.13.3 Pain syndromes - childhood onset; 6.14 Osteoarthritis; 6.15 Crystal arthropathies; 6.16.1 Osteoporosis and osteomalacia; 6.16.2 Paget's disease of bone; 6.16.3 Miscellaneous disorders of bone, cartilage and synovium; 6.16.4 Diseases of bone and cartilage in children; 6.17 Disorders of the spine; 6.17.1 Intevertebral disc disease and other mechanical disorders of the back; 6.17.2 Cervical pain syndromes; 6.18.1 Algodystrophy; 6.18.2 Rheumatic complications of drugs and toxins; SECTION 7: SURGICAL INTERVENTION AND SPORTS MEDICINE; 7.1 Surgery in adults; 7.2 Surgery in children; 7.3 Corticosteroid injection therapy; 7.4 Sports medicine; 7.5 Sports injuries