Selenium

Part I. The machinery of selenoprotein biosynthesis.- 1 Selenocysteine tRNA[Ser]Sec: From nonsense suppressor tRNA to the quintessential constituent in selenoprotein biosynthesis.- 2 Eukaryotic mechanisms of selenocysteine translation and its reconstitution in vitro.- 3 Probing selenoprotein translation by ribosome profiling.- 4 Pathways in de novo biosynthesis of selenocysteine and cysteine in eukaryotes.- 5 Prokaryotic selenoprotein biosynthesis and function.- 6 The role of selenium in human evolution.- 7 The chemistry of selenocysteine in proteins.- 8 Evolution of selenophosphate synthetase.- 9 Structure and mechanism of selenocysteine synthases.- 10 Mechanism, structure, and biological role of selenocysteine lyase.- Part II. Selenoproteins, their occurrence and function.- 11 Eukaryotic selenoproteomes.- 12 Prokaryotic selenoproteins and selenoproteomes.- 13 Functional genomics of selenoproteins and Se-responsive pathways.- 14 Selenium regulation of the selenoprotein and non-selenoprotein transcriptomes in a variety of species.- 15 77Se NMR spectroscopy of selenoproteins.- 16 Thioredoxin reductase 1 as an anticancer drug target.- 17 Basics and news on glutathione peroxidases.- 18 Glutathione Peroxidase 4.- 19 The 15 kDa Selenoprotein: Insights into its regulation and function.- 20 Selenoprotein K and protein palmitoylation in regulating immune cell functions.- 21 Selenoprotein M: Structure, expression and functional relevance.- 22 Selenoprotein P and selenium distribution in mammals.- 23 Selenoprotein T: From discovery to functional studies using conditional knockout mice.- 24 Biochemistry and function of methionine sulfoxide reductase.- Part III. Dietary selenium and its impact on human health.- 25 Selenium: Dietary sources, human nutritional requirements and intake across populations.- 26 Human clinical trials involving selenium.- 27 Status of dietary selenium in cancer prevention.- 28 Selenium in HIV/AIDS.- 29 Genetic variations in the genes for selenoproteinsimplicate the encoded proteins in cancer etiology.- 30 Is adequate selenium important for healthy human pregnancy?.- 31 The epidemiology of selenium and human health.- 32 Sex-specific differences in biological effects and metabolism of selenium.- 33 Selenium and endocrine tissues.- 34 Selenium antagonism with mercury and arsenic: from chemistry to population health and demography.- 35 Biological selenium species and selenium speciation in biological samples.- 36 Selenoproteins in nervous system development, function and degeneration.- 37 Interplay of selenoproteins and different antioxidant systems in various cancers.- 38 Glutathione peroxidase 2, a selenoprotein exhibiting a dual personality in preventing and promoting cancer.- 39 Selenoproteins in cardiovascular redox pathology.- 40 What do we know about selenium contributions to muscle physiology?.- 41 Tissue-specific regulation of thyroid status by selenodeiodinases.- 42 The role of selenoproteins in resolution of inflammation.- 43 Glutathione peroxidase 4 and ferroptosis.- 44 Mutations in humans that adversely affect the selenoprotein synthesis pathway.- 45 Alteration of selenoprotein expression during stress and in aging.- Part V. Biological models for elucidating the role of selenium and selenoproteins in biology and medicine.- 46 Selenocysteine tRNA[Ser]Sec mouse models for elucidating roles of selenoproteins in health and development.- 47 Mouse models that target individual selenoproteins.- 48 The naked mole rat and selenium.- 49 Glutathione peroxidase 1: Models for diabetes and obesity.- 50 Selenium in livestock and other domestic animals