Guidelines for Process Safety in Chemical Laboratories and Pilot Plants
A Risk-based Approach
Published on 2. August 2023
Book
Hardback
400 pages
978-1-119-01013-5 (ISBN)
Description
This book provides guidance on "what" can be done from a management systems perspective to identify hazards and manage risks of "loss of containment" events in chemical laboratories and pilot plants. It provides examples of "how to" implement such practices and descriptions of a range of typically encountered process safety hazards typical controls based on current best practices.
More details
Edition
1. Auflage
Language
English
Place of publication
United States
Publishing group
John Wiley & Sons Inc
Target group
Professional and scholarly
Product notice
sewn/stitched
Cloth over boards
Dimensions
Height: 259 mm
Width: 184 mm
Thickness: 33 mm
Weight
1122 gr
ISBN-13
978-1-119-01013-5 (9781119010135)
Schweitzer Classification
Other editions
Additional editions
(Center For Chemical Process Safety) Ccps
Handbook for Process Safety in Laboratories and Pilot Plants
A Risk-based Approach
E-Book
08/2023
1st Edition
Wiley
€164.99
Available for download
(Center For Chemical Process Safety) Ccps
Handbook for Process Safety in Laboratories and Pilot Plants
A Risk-based Approach
E-Book
07/2023
1st Edition
Wiley
€164.99
Available for download
Person
Since 1985, the Center for Chemical Process Safety (CCPS) has been the global leader in developing and disseminating information on process safety management and technology. CCPS, an industry technology alliance of the American Institute of Chemical Engineers (AIChE), has published over 100 books in its process safety guidelines and process safety concepts series, and over 100 training modules through its Safety in Chemical Engineering Education (SACHE) series.
Content
List of Figures x
List of Tables xi
Abbreviations and Acronyms xii
Glossary xv
Acknowledgments xxii
Dedication xxiv
Online Materials Accompanying this Handbook xxv
Preface xxvii
Part 1 - Introduction and Overview 1
1 Purpose and Scope 3
1.1 Purpose 3
1.2 Scope of Book and Target Audience 4
1.3 Terms for Laboratories and Pilot Plants 5
1.4 Distinctions between Laboratories and Pilot Plants 7
1.5 Organization of This Handbook 8
2 Managing Risk to Prevent Incidents 13
2.1 Some LAPP Characteristics 13
2.2 Safety in Laboratories and Pilot Plants 24
2.3 Where to Start with a Risk-based Approach in the LAPP 25
2.4 Gain Leadership Support to Implement Risk Based Process Safety 29
2.5 Laboratory Safety Management System Considerations 29
2.6 Resources for Risk Based Process Safety Management System 31
3 Leaks and Spills in the LAPP 35
3.1 Leaks of Hazardous Materials 35
3.2 Spills of Hazardous Materials 38
Part 2 - Committing to Process Safety 39
4 LAPP Risk Management Concepts 41
4.1 Occupational Safety and Process Safety 41
4.2 Hierarchy of Controls 41
4.3 Inherently Safer Design (ISD) 42
4.4 Basic Risk Concepts 44
4.5 A Risk Management Program 47
4.6 Anatomy of an Incident 48
4.7 Preventive and Mitigative Safeguards 49
4.8 Applying a Risk-Based Approach in a LAPP 51
5 Process Safety Culture in the LAPP 55
5.1 RBPS Element 1: Process Safety Culture 55
5.2 Leaders' Responsibilities for Positive Safety Culture 58
5.3 Resources and Examples for Process Safety Culture 59
6 Standards for the LAPP 63
6.1 RBPS Element 2: Compliance with Standards 63
6.2 Risk Management Focus 65
6.3 Different Codes and Standards When Scaling Up from Laboratory to Pilot Plant 65
6.4 Jurisdictional Requirements 67
6.5 Resources for Compliance with Standards 67
7 Process Safety Competency and Training in the LAPP 69
7.1 RBPS Element 3: Process Safety Competency 69
7.2 RBPS Element 12: Training and Performance Assurance 72
8 Workforce Involvement and Stakeholder Outreach in the LAPP 79
8.1 RBPS Element 4: Workforce Involvement 79
8.2 RBPS Element 5: Stakeholder Outreach 82
Part 3 - Understanding Hazards and Risks 83
9 Process Safety Knowledge Management in the LAPP 85
9.1 RBPS Element 6: Process Knowledge Management 85
9.2 Overview of Information and Data Needs 86
9.3 Sources of Information and Data 89
9.4 Process Safety Information during Scale-up 92
10 Types of Hazards 95
10.1 Reactive Chemistry Hazards 95
10.2 Toxicity Hazards 115
10.3 Flammability and Combustibility Hazards 121
10.4 Temperature Hazards 137
10.5 Overpressure Hazards 140
10.6 Other Common LAPP Hazards 142
Table of Contents vii ix
11 Hazard Identification and Risk Analysis (HIRA) in the LAPP 153
11.1 RBPS Element 7: Hazard Identification and Risk Analysis 153
11.2 HIRA Team Members 156
11.3 HIRA Approaches Used in LAPPs 156
11.4 Qualitative versus Quantitative Analysis of Risks in LAPPs 165
11.5 ACS Hazard Analysis Tools 168
11.6 Evaluating the Effort Level for HIRAs 168
11.7 Determining the Extent of the HIRAs 169
Part 4 - Managing Risk: Engineered Controls 171
12 Spill and Leak Protection 173
12.1 Containment 173
12.2 Flexible hose and tubing 173
13 Fire and Over-Temperature Protection 175
13.1 Fire Prevention 175
13.2 Fire Mitigation 183
13.3 Over-Temperature Protection 185
14 Overpressure Prevention and Protection 191
14.1 Pressure Protection for Equipment 191
14.2 Pressure and Vacuum Relief for Atmospheric Pressure Vessels 196
14.3 Process Conditions/Situations to Consider in Pressure Relief Device Design 197
14.4 Blast Containment Cells and Pressure Relief for Building Areas 198
14.5 Venting Location and Downstream Treatment of Material Vented 201
15 Ventilation Controls 203
15.1 Ventilation Systems 203
15.2 Laboratory Chemical Fume Hoods 205
15.3 Pilot Plant Ventilation 207
15.4 Permanent Total Enclosures for Containment in the LAPP 207
16 Automated Shut-down Systems 209
16.1 Selection and Design Based on Hazard Identification and Risk Analysis 209
16.2 Basic Control Systems and Safety Shut-down Systems 209
16.3 Independent Automated Safety Shut-down Systems 210
16.4 Fail-Safe Design Considerations 212
16.5 Important Design Features for Control Systems 212
16.6 Control of Changes and Maintenance for Engineered Safeguards 214
16.7 Additional References 215
17 Engineered Controls for Common Hazards 217
17.1 Cryogenic Fluids and Compressed Gases 217
17.2 Cryogenic Fluids and Compressed Gas Cylinders 218
17.3 Glass Equipment 228
17.4 Gloveboxes 228
Part 5 - Managing Risk: Administrative Controls 235
18 Administrative Fire and Explosion Safeguards 237
18.1 Standards and Guidance for Fire Prevention 237
18.2 Ignition Source Control: Procedures 237
18.3 Manual Fire Suppression 238
19 Administrative Safeguards for Hazards in LAPPs 239
19.1 Good Practices for Compressed Gas and Cryogenic Cylinders 239
19.2 Regulations and Standards for Compressed Gases and Cryogenic Fluids 239
19.3 Procedures and Best Practices for Compressed Gases 241
19.4 Good Practices for Storage, Movement, and Use of Cryogenic Fluids 248
19.5 Good Practices For Handling Glass 251
19.6 Administrative Controls for Reactive Hazards 251
Part 6 - Managing Risk: RBPS Management Systems 253
20 Operating Procedures and Conduct of Operations in the LAPP 255
20.1 RBPS Element 8: LAPP Operating Procedures 255
20.2 RBPS Element 15: Conduct of Operations 260
21 Safe Work Practices and Contractor Management in the LAPP 263
21.1 RBPS Element 9: Safe Work Practices 263
21.2 RBPS Element 11: Contractor Management 266
22 Asset Integrity and Reliability in the LAPP 269
22.1 RBPS Element 10: Asset Integrity and Reliability 269
22.2 A Management Approach for Assuring Asset Integrity and Reliability 270
22.3 Examples of Asset Integrity and Reliability Management System Failures 271
22.4 Glass Equipment-Asset Integrity and Reliability Challenge for LAPPs 274
23 Management of Change (MOC) and Operational Readiness in the LAPP 277
23.1 RBPS Element 13: Management of Change 277
23.2 RBPS Element 14: Operational Readiness 281
Table of Contents ix xi
24 Emergency Management in the LAPP 283
24.1 RBPS Element 16: Emergency Management 283
24.2 Emergency Planning 283
24.3 Implementing an Emergency Management Plan 284
24.4 Emergency Equipment 285
24.5 Training and Drills 285
24.6 Deficiencies in Emergency Planning and Response in LAPP Cases 286
24.7 Controlling Unattended Experimental Work and Working Alone in LAPPs 288
Part 7 - Learning from Experience 291
25 Investigating Incidents 293
25.1 Incident Terminology 293
25.2 RBPS Element 17: Incident Investigation 294
25.3 Steps of an Incident Investigation 295
25.4 Ensure Lessons Are Learned and Remembered 298
25.5 Learn from Experience of Others 298
26 Metrics, Auditing, and Management Review in the LAPP 299
26.1 RBPS Element 18: Measurement and Metrics 299
26.2 RBPS Element 19: Auditing 300
26.3 RBPS Element 20: Management Review and Continuous Improvement 302
Part 8 - Conclusion 305
References 307
Appendix A Cases 323
Appendix B Examples 453
Appendix C Control Banding Strategies 501
Appendix D Glass Equipment Design 517
Index 525
List of Tables xi
Abbreviations and Acronyms xii
Glossary xv
Acknowledgments xxii
Dedication xxiv
Online Materials Accompanying this Handbook xxv
Preface xxvii
Part 1 - Introduction and Overview 1
1 Purpose and Scope 3
1.1 Purpose 3
1.2 Scope of Book and Target Audience 4
1.3 Terms for Laboratories and Pilot Plants 5
1.4 Distinctions between Laboratories and Pilot Plants 7
1.5 Organization of This Handbook 8
2 Managing Risk to Prevent Incidents 13
2.1 Some LAPP Characteristics 13
2.2 Safety in Laboratories and Pilot Plants 24
2.3 Where to Start with a Risk-based Approach in the LAPP 25
2.4 Gain Leadership Support to Implement Risk Based Process Safety 29
2.5 Laboratory Safety Management System Considerations 29
2.6 Resources for Risk Based Process Safety Management System 31
3 Leaks and Spills in the LAPP 35
3.1 Leaks of Hazardous Materials 35
3.2 Spills of Hazardous Materials 38
Part 2 - Committing to Process Safety 39
4 LAPP Risk Management Concepts 41
4.1 Occupational Safety and Process Safety 41
4.2 Hierarchy of Controls 41
4.3 Inherently Safer Design (ISD) 42
4.4 Basic Risk Concepts 44
4.5 A Risk Management Program 47
4.6 Anatomy of an Incident 48
4.7 Preventive and Mitigative Safeguards 49
4.8 Applying a Risk-Based Approach in a LAPP 51
5 Process Safety Culture in the LAPP 55
5.1 RBPS Element 1: Process Safety Culture 55
5.2 Leaders' Responsibilities for Positive Safety Culture 58
5.3 Resources and Examples for Process Safety Culture 59
6 Standards for the LAPP 63
6.1 RBPS Element 2: Compliance with Standards 63
6.2 Risk Management Focus 65
6.3 Different Codes and Standards When Scaling Up from Laboratory to Pilot Plant 65
6.4 Jurisdictional Requirements 67
6.5 Resources for Compliance with Standards 67
7 Process Safety Competency and Training in the LAPP 69
7.1 RBPS Element 3: Process Safety Competency 69
7.2 RBPS Element 12: Training and Performance Assurance 72
8 Workforce Involvement and Stakeholder Outreach in the LAPP 79
8.1 RBPS Element 4: Workforce Involvement 79
8.2 RBPS Element 5: Stakeholder Outreach 82
Part 3 - Understanding Hazards and Risks 83
9 Process Safety Knowledge Management in the LAPP 85
9.1 RBPS Element 6: Process Knowledge Management 85
9.2 Overview of Information and Data Needs 86
9.3 Sources of Information and Data 89
9.4 Process Safety Information during Scale-up 92
10 Types of Hazards 95
10.1 Reactive Chemistry Hazards 95
10.2 Toxicity Hazards 115
10.3 Flammability and Combustibility Hazards 121
10.4 Temperature Hazards 137
10.5 Overpressure Hazards 140
10.6 Other Common LAPP Hazards 142
Table of Contents vii ix
11 Hazard Identification and Risk Analysis (HIRA) in the LAPP 153
11.1 RBPS Element 7: Hazard Identification and Risk Analysis 153
11.2 HIRA Team Members 156
11.3 HIRA Approaches Used in LAPPs 156
11.4 Qualitative versus Quantitative Analysis of Risks in LAPPs 165
11.5 ACS Hazard Analysis Tools 168
11.6 Evaluating the Effort Level for HIRAs 168
11.7 Determining the Extent of the HIRAs 169
Part 4 - Managing Risk: Engineered Controls 171
12 Spill and Leak Protection 173
12.1 Containment 173
12.2 Flexible hose and tubing 173
13 Fire and Over-Temperature Protection 175
13.1 Fire Prevention 175
13.2 Fire Mitigation 183
13.3 Over-Temperature Protection 185
14 Overpressure Prevention and Protection 191
14.1 Pressure Protection for Equipment 191
14.2 Pressure and Vacuum Relief for Atmospheric Pressure Vessels 196
14.3 Process Conditions/Situations to Consider in Pressure Relief Device Design 197
14.4 Blast Containment Cells and Pressure Relief for Building Areas 198
14.5 Venting Location and Downstream Treatment of Material Vented 201
15 Ventilation Controls 203
15.1 Ventilation Systems 203
15.2 Laboratory Chemical Fume Hoods 205
15.3 Pilot Plant Ventilation 207
15.4 Permanent Total Enclosures for Containment in the LAPP 207
16 Automated Shut-down Systems 209
16.1 Selection and Design Based on Hazard Identification and Risk Analysis 209
16.2 Basic Control Systems and Safety Shut-down Systems 209
16.3 Independent Automated Safety Shut-down Systems 210
16.4 Fail-Safe Design Considerations 212
16.5 Important Design Features for Control Systems 212
16.6 Control of Changes and Maintenance for Engineered Safeguards 214
16.7 Additional References 215
17 Engineered Controls for Common Hazards 217
17.1 Cryogenic Fluids and Compressed Gases 217
17.2 Cryogenic Fluids and Compressed Gas Cylinders 218
17.3 Glass Equipment 228
17.4 Gloveboxes 228
Part 5 - Managing Risk: Administrative Controls 235
18 Administrative Fire and Explosion Safeguards 237
18.1 Standards and Guidance for Fire Prevention 237
18.2 Ignition Source Control: Procedures 237
18.3 Manual Fire Suppression 238
19 Administrative Safeguards for Hazards in LAPPs 239
19.1 Good Practices for Compressed Gas and Cryogenic Cylinders 239
19.2 Regulations and Standards for Compressed Gases and Cryogenic Fluids 239
19.3 Procedures and Best Practices for Compressed Gases 241
19.4 Good Practices for Storage, Movement, and Use of Cryogenic Fluids 248
19.5 Good Practices For Handling Glass 251
19.6 Administrative Controls for Reactive Hazards 251
Part 6 - Managing Risk: RBPS Management Systems 253
20 Operating Procedures and Conduct of Operations in the LAPP 255
20.1 RBPS Element 8: LAPP Operating Procedures 255
20.2 RBPS Element 15: Conduct of Operations 260
21 Safe Work Practices and Contractor Management in the LAPP 263
21.1 RBPS Element 9: Safe Work Practices 263
21.2 RBPS Element 11: Contractor Management 266
22 Asset Integrity and Reliability in the LAPP 269
22.1 RBPS Element 10: Asset Integrity and Reliability 269
22.2 A Management Approach for Assuring Asset Integrity and Reliability 270
22.3 Examples of Asset Integrity and Reliability Management System Failures 271
22.4 Glass Equipment-Asset Integrity and Reliability Challenge for LAPPs 274
23 Management of Change (MOC) and Operational Readiness in the LAPP 277
23.1 RBPS Element 13: Management of Change 277
23.2 RBPS Element 14: Operational Readiness 281
Table of Contents ix xi
24 Emergency Management in the LAPP 283
24.1 RBPS Element 16: Emergency Management 283
24.2 Emergency Planning 283
24.3 Implementing an Emergency Management Plan 284
24.4 Emergency Equipment 285
24.5 Training and Drills 285
24.6 Deficiencies in Emergency Planning and Response in LAPP Cases 286
24.7 Controlling Unattended Experimental Work and Working Alone in LAPPs 288
Part 7 - Learning from Experience 291
25 Investigating Incidents 293
25.1 Incident Terminology 293
25.2 RBPS Element 17: Incident Investigation 294
25.3 Steps of an Incident Investigation 295
25.4 Ensure Lessons Are Learned and Remembered 298
25.5 Learn from Experience of Others 298
26 Metrics, Auditing, and Management Review in the LAPP 299
26.1 RBPS Element 18: Measurement and Metrics 299
26.2 RBPS Element 19: Auditing 300
26.3 RBPS Element 20: Management Review and Continuous Improvement 302
Part 8 - Conclusion 305
References 307
Appendix A Cases 323
Appendix B Examples 453
Appendix C Control Banding Strategies 501
Appendix D Glass Equipment Design 517
Index 525