Non-Myeloablative Allogeneic Transplantation
Published on 30. October 2012
Book
Paperback/Softback
X, 216 pages
978-1-4613-5304-1 (ISBN)
Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
More details
Series
Edition
Softcover reprint of the original 1st ed. 2002
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Professional/practitioner
Illustrations
X, 216 p.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 13 mm
Weight
359 gr
ISBN-13
978-1-4613-5304-1 (9781461353041)
DOI
10.1007/978-1-4615-0919-6
Schweitzer Classification
Other editions
Additional editions
Asad Bashey | Edward D. Ball
Non-Myeloablative Allogeneic Transplantation
E-Book
12/2012
Springer
€96.29
Available for download
Asad Bashey | Edward D. Ball
Non-Myeloablative Allogeneic Transplantation
Book
02/2002
Kluwer Academic Publishers
€106.99
Shipment within 15-20 days
Content
1 Development of allogeneic hematopoietic stem cell transplantation (HSCT).- 2 Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in nonmyeloablative hematopoietic cell transplantation.- 3 Mobilization of allogeneic peripheral blood progenitor cells.- 4 Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologicmalignancies in experimental and clinical studies.- 5 Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer.- 6 Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice.- 7 Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy.- 8 Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans.- 9 Non-myeloablative transplants for congenital diseases.