Non-Myeloablative Allogeneic Transplantation
Published on 28. February 2002
Book
Hardback
X, 216 pages
978-0-7923-7646-0 (ISBN)
Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.
More details
Series
Edition
2002 ed.
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Professional/practitioner
Product notice
sewn/stitched
Cloth over boards
Illustrations
X, 216 p.
Dimensions
Height: 242 mm
Width: 163 mm
Thickness: 18 mm
Weight
526 gr
ISBN-13
978-0-7923-7646-0 (9780792376460)
DOI
10.1007/978-1-4615-0919-6
Schweitzer Classification
Other editions
Additional editions
Asad Bashey | Edward D. Ball
Non-Myeloablative Allogeneic Transplantation
Book
10/2012
Springer
€106.99
Shipment within 7-9 days
Content
1 Development of allogeneic hematopoietic stem cell transplantation (HSCT).- 2 Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in nonmyeloablative hematopoietic cell transplantation.- 3 Mobilization of allogeneic peripheral blood progenitor cells.- 4 Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologicmalignancies in experimental and clinical studies.- 5 Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer.- 6 Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice.- 7 Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy.- 8 Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans.- 9 Non-myeloablative transplants for congenital diseases.