Novartis Foundation Symposium 264 - Nuclear Organization in Development and Disease
Published on 7. October 2008
Software
Other digital
300 pages
978-0-470-09376-4 (ISBN)
Description
This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include:* How nuclear structure and location within a nucleus affect gene expression* Chromatin organization and cell differentiation* The nature of the interactions between the nuclear envelope and the cytoskeleton* The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.
Reviews / Votes
"...an excellent guide to research in the field of nuclear organization, and an encouragement for students interested in learning how great minds tackle complex problems." (Doody's Health Services)More details
Language
English
Place of publication
Chichester
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
Professional and scholarly
Dimensions
Height: 237 mm
Width: 165 mm
Thickness: 19 mm
Weight
612 gr
ISBN-13
978-0-470-09376-4 (9780470093764)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Derek J. Chadwick | Jamie A. Goode
Nuclear Organization in Development and Disease
Novartis Foundation Symposium
E-Book
08/2005
Wiley
€161.99
Available for download
Person
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: Robert D. Goldman
Content
Chair's Introduction (R. Goldman). Nuclear lamins: building blocks of nuclear structure and function (R. Goldman, et al.). Aspects of nuclear envelope dynamics in mitotic cells (B. Burke, et al.). Components of the nuclear envelope and their role in human disease (H. Worman). Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease (K. Wilson, et al.). Identification of novel integral membrane proteins of the nuclear envelope with potential disease links using subtractive proteomics (E. Schirmer, et al.). Genetics of laminopathies (R. Ben Yaou, et al.). Muscular dystrophies related to the cytoskeleton/nuclear envelope (K. Nowak, et al.). Skeletal and cardiac muscle defects in a murine model of Emery-Dreifuss muscular dystrophy (M. Grattan, et al.). Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for Sir-mediated repression (A. Taddei, et al.). A-type lamin-linked lipodystrophies (C. Vigouroux and J. Capeau). Cytoskeletal defects in amyotrophic lateral sclerosis (motor neuron disease) (J. Julien, et al.). LMNA mutations in progeroid syndromes (S. Huang, et al.). A genetic approach to study the role of nuclear envelope components in nuclear positioning (D. Starr and M. Han). General Discussion I. A lamin-dependent pathway that regulates nuclear organization, cell cycle progression and germ cell development (A. Margalit, et al.). Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and cardiomyopathy (S. Kozlov, et al.). The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C-deficient cells (J. Lammerding and R. Lee). Chair's summing up (R. Goldman). Index of contributors. Subject index.