The Interferons - Characterization and Application
Published on 6. June 2006
Software
Other digital
460 pages
978-3-527-60820-1 (ISBN)
Description
At long last, this is the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. It is intended for immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.
Reviews / Votes
"Wer sich mit Interferonen im engeren oder weiteren Sinn beschaftigt, bekommt hier eine Ubersicht geboten, die deutlich mehr ist, als ein blo?er Einstieg. So wird dieses Buch mit Sicherheit seine Leserschaft finden." Pharmazie in unserer Zeit "...dieses Buch, das fur jeden, der sich fur die aktuelle wissenschaftliche Information zu den Interferonen interessiert, au?erst wertvoll ist. Herausragend sind neben dem geschriebenen Inhalt die hervorragenden Graphiken, die den Text sehr gut erlautern und die teilweise schwierige Materie gut verstehen lasst. Forschern wie Lehrern der Immunologie und angrenzender Gebiete sei dieses Buch daher empfohlen." Arzneimittel-Forschung / Drug ResearchMore details
Language
English
Place of publication
Weinheim
Germany
Target group
Professional and scholarly
Dimensions
Height: 246 mm
Width: 186 mm
Thickness: 27 mm
Weight
992 gr
ISBN-13
978-3-527-60820-1 (9783527608201)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
08/2006
1st Edition
Wiley-Blackwell
€151.99
Available for download
Person
Anthony Meager is a Principal Scientist in the Division of Immunology and Endocrinology, The National Institute for Biological Standards and Control (NIBSC), UK. Following his PhD in Biochemistry (Warwick University, UK, 1972), he has carried out research in biochemistry, cell biology, immunology, virology, and cytokines, especially interferons (IFN) and tumor necrosis factor (TNF). He joined the NIBSC in 1980. Currently, he heads laboratories involved in the biological standardization of IFN and TNF, and research studies on the bioactivity and immunogenicity of cytokines. From 1990, he has also contributed to regulatory guidance on gene therapy, both for the European Medicines Agency and the World Health Organization.
Content
Preface.List of Contributors.Color Plates.Section A: Molecular Aspects, Introduction and Purification.1 Type I Interferons: Genetics and Structure (Shamith A. Samarajiwa, William Wilson and Paul J. Hertzog).1.1 Introduction.1.2 The Type I IFN Genetic Locus.1.3 Type I IFN Genes.1.4 Type I IFN Gene-regulatory Regions.1.5 Evolution of the Type I IFNs.1.6 Natural and Induced Mutations in IFN Genes.1.7 Secondary Structural Features of Type I IFNs.1.8 The Structure of Type I IFNs.2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways (Peyman Nakhaei, Suzanne Paz and John Hiscott).2.1 Introduction.2.2 IFN-beta Gene Transcription.2.3 IRF Family Members.2.4 Role of IRFs in Virus-mediated IFN Activation.2.5 IFN Signaling Pathways.2.6 Conclusions.3 Interferon Proteins: Structure, Production and Purification (Dimitris Platis and Graham R. Foster).3.1 Introduction.3.2 The Structure of Type I IFNs.3.3 Production and Purification of Type I IFNs.3.4 Long-acting IFNs.3.5 Summary.4 Interferon-g: Gene and Protein Structure, Transcription Regulation, and Actions (Ana M. Gamero, Deborah L. Hodge, David M. Reynolds, Maria Cecilia Rodriguez-Galan, Mansour Mohamadzadeh and Howard A. Young).4.1 Introduction.4.2 IFN-gamma Gene Structure and Regulation.4.3 IFN--gamma Signal Transduction.4.4 IFN--gamma in Th Cell Development.4.5 IFN--gamma and DCs.4.6 IFN--gamma - Role in Tumor Development and Growth.4.7 Summary.5 Interferon and Related Receptors (Sidney Pestka and Christopher D. Krause).5.1 Introduction.5.2 IFNs and IFN-like Molecules in Brief.5.3 The Receptors.5.4 The Type I IFN Receptor.5.5 The Type II IFN (IFN-g) Receptor.5.6 The IL-28R1 and -10R2 Receptor Complex.5.7 Overview of Multichain Receptors.5.8 Global Summary.6 Type III Interferons: The Interferon-l Family (Sergei V. Kotenko and Raymond P. Donnelly).6.1 Introduction.6.2 The Class II Cytokine Receptor Family (CRF2) and their Ligands.6.3 Genomic Structure.6.4 Receptor Complex and Signaling.6.5 Biological Activities.6.6 The Murine IFN-l Antiviral System.6.7 Evolution of the IFN Family.6.8 Therapeutic Potential.6.9 Conclusions.Section B: Biological Properties.7 Biological Actions of Type I Interferons (Melissa M. Brierley, Jyothi Kumaran and Eleanor N. Fish).7.1 Introduction.7.2 Sources of Type I IFN Production and Secretion.7.3 Type I IFN Interactions with the Receptor Complex.7.4 Type I IFN-induced Signaling Cascades.7.5 IFN-inducible Biological Responses.7.6 Summary.8 Interferons and Apoptosis - Recent Developments (Michael J. Clemens and Ian W. Jeffrey).8.1 Introduction.8.2 The Role of IFN-regulated Genes in the Control of Apoptosis.8.3 The Protein Kinase PKR and the Phosphorylation of Polypeptide Chain Initiation Factor eIF2alpha.8.4 IFNs and the Apoptotic Effects of TRAIL.8.5 Signal Transduction Pathways for IFN-mediated Effects on Apoptosis.8.6 The Antiapoptotic Effects of IFNs.8.7 Conclusions.9 Viral Defense Mechanisms against Interferon (Santanu Bose and Amiya K. Banerjee).9.1 Introduction.9.2 Innate Immune Antiviral Defense Mechanisms of Host Cells.9.3 Evasion of IFN-mediated Antiviral Response.9.4 Concluding Remarks.Section C: Clinical Applications.10 Overview of Clinical Applications of Type I Interferons (Frank Muller).10.1 Introduction.10.2 Biological Effects.10.3 Type I IFN Products Currently Available or Under Development.10.4 Pharmacokinetics.10.5 Clinical Applications of Type I Interferons.10.6 IFN Toxicity.10.7 Type I IFNs in the Future.11 Clinical Applications of Interferon-gamma (Christine W. Czarniecki and Gerald Sonnenfeld).11.1 Introduction.11.2 IFN-gamma - The Molecule.11.3 FDA-approved Indications: Established Benefit and Risks.11.4 Infectious Diseases.11.5 Infection Following Serious Trauma.11.6 Atopic Dermatitis (AD).11.7 Idiopathic Pulmonary Fibrosis (IPF).11.8 Systemic Sclerosis (SSc).11.9 Radiation-induced Fibrosis.11.10 Chronic Hepatitis.11.11 Oncology Indications: Ovarian Cancer.11.12 Conclusions.Section D: Measurement of Interferons and Anti-Interferons.12 Measurement of Interferon Activities (Tony Meager).12.1 Introduction.12.2 The IFNs: Mechanisms of Action, Protein Induction and Biological Activities.12.3 Measurement of Biological Activities of IFNs.12.4 Regulatory Landscape.13 The Development and Measurement of Antibodies to Interferon (Sidney E. Grossberg and Yoshimi Kawade).13.1 Introductory Perspective.13.2 NAbs.13.3 Immunoassays for Non-NAbs.13.4 Epitope Analysis.13.5 Development of Antibodies during IFN Therapy.13.6 Summary.Index.