Artificial Enzymes
Published on 24. March 2006
Software
Other digital
193 pages
978-3-527-60664-1 (ISBN)
Description
This first book on this fascinating topic is edited by one of today's most famous and internationally respected organic chemists, renowned for his pioneering synthesis of the cyclopropenyl cation. For his part, Ronald Breslow has brought together leading scientists in this expanding area to provide a novel overview of protein-, cyclodextrin-, metal- and porphyrin-based artificial enzymes as well as enzyme-like polymers and dendrimers. It is a must for all scientists interested in this emerging field.
Reviews / Votes
"This text will be of interest to biochemists and pharmaceutical researchers." (The Catalyst, January 2007) "...a highly readable introduction to this creative chemical discipline...fills a critical gap in the literature of bioorganic/supramolecular chemistry." (Journal of the American Chemical Society, April 12, 2006) "The book is a very nice addition to our understanding of artificial enzymes." (Angewandte Chemie International Edition)More details
Language
English
Place of publication
Weinheim
Germany
Target group
Professional and scholarly
Weight
10 gr
ISBN-13
978-3-527-60664-1 (9783527606641)
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Schweitzer Classification
Content
Preface.List of Authors.1 Artificial Enzymes (Ronald Breslow).1.1 Mimics of Enzymes that use Thiamine Pyrophosphate as a Coenzyme.1.2 Mimics of Enzymes that use Pyridoxamine and Pyridoxal Phosphates as Coenzymes.1.3 Artificial Hydrolytic Enzymes.1.4 Cytochrome P-450 Mimics.1.5 Future Prospects.2 Vitamin B6 Enzyme Models (Lei Liu and Ronald Breslow).2.1 Introduction.2.2 Transamination.2.3 Racemization.2.4 Decarboxylation.2.6 Aldolase-type Reactions.3 Evolution of Synthetic Polymers with Enzyme-like Catalytic Activities (Irving M. Klotz and Junghun Suh).3.1 Introduction: Conceptual Background.3.2 Homogeneous Polymer Biocatalysts.3.3 Heterogeneous Polymer Biocatalysts.3.4 Prospectives.4 Mimicking Enzymes with Antibodies (Donald Hilvert).4.1 Introduction.4.2 Basic Strategy.4.3 Evolution of Binding Affinity and Catalytic Efficiency.4.4 Importance of a Good Fit.4.5 General Acid-General Base Catalysis.4.6 Covalent Catalysis.4.7 Practical Applications.4.8 Future Directions.4.9 Outlook.5 Protein-based Artificial Enzymes (Ben Duckworth and Mark D. Distefano).5.1 Introduction.5.2 Artificial Nucleases Based on DNA and RNA Binding Proteins.5.3 Catalysts Based on Hollow Lipid-binding Proteins.5.4 Myoglobin as a Starting Point for Oxidase Design.5.5 Antibodies as Scaffolds for Catalyst Design.5.6 Conclusions.6 Artificial Hydrolytic Metalloenzymes (Jik Chin and Hae-Jo Kim).6.1 Introduction.6.2 Reactivity of Substrates.6.3 Lewis Acid Activation.6.4 Nucleophile Activation.6.5 Leaving-group Activation.6.6 Combining Lewis Acid Activation and Nucleophile Activation.6.7 Double Lewis Acid Activation.6.8 Phosphatase Models.6.9 Phosphodiesterase Models.6.10 Polymerases and DNases.6.11 Conclusion.7 Artificial Restriction Enzymes As Tools For Future Molecular Biology and Biotechnology (Yoji Yamamoto and Makoto Komiyama).7.1 Introduction.7.2 Significance of Artificial Restriction Enzymes.7.3 Non-enzymatic Catalysts for DNA Hydrolysis.7.4 Molecular Design of Artificial Restriction Enzymes (Covalent vs. Non-Covalent Strategy).7.5 Site-selective Scission of Single-stranded DNA.7.6 Site-selective Scission of Double-stranded DNA by Combining Ce(IV)/EDTA Complex with Pseudo-complementary PNA.7.7 Conclusion.Index.